Presurgical Evaluation of Nonmelanoma Skin Cancers Using High Frequency Ultrasound
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Assiut University
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Complete excision of nonmelanoma skin cancers
Study Overview
Brief Summary
- To ensure complete elimination of lesions with maximum preservation of function and aesthetics.
- To elaborate the Ultrasonographic features of skin cancers.
- To determine the accuracy of HIFU to assess the margins of skin lesions and its safety margins by histopathiological examination..
- To follow up the patient postoperatively for incomplete excision or recurrence by clinical and HIFU examination.
Detailed Description
The skin is the most superficial and largest body organ, due to its function as a surface covering for the body, enables the performance of noninvasive diagnostic and investigative procedures.
Of all the tumors that affect humans, non-melanoma cutaneous cancer is the most common e.g. basal cell carcinoma (BCC) and squamous cell carcinoma (SCC).
Techniques such as high frequency ultrasound (HFUS) enable the real-time study of cutaneous lesions, making them excellent pre-operative tools varying considerably in their penetration, resolution, and applicability.
High frequency ultrasound has been used in dermatology since the 1970s, ultrasonography is a painless non-radioactive imaging diagnostic method based on the reflection of sound waves through body tissues.
High frequency ultrasound allows for the delimiting of the margins of the neoplasia, due to the difference in echogenicity between the hypoechoic tumoral area and the hyperechoic perilesional area.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Supportive Care
- Masking
- None
Eligibility Criteria
- Ages
- 30 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients between 30 & 80 years.
- •Lesions clinically apparent locally malignant, or malignant.
- •Lesions with or without visible ulcerations.
Exclusion Criteria
- •Surgeon unable to visualize tumor on clinical examination.
- •Patients unfit for surgery.
Arms & Interventions
Patients with skin lesions
Using HIFU in identification of safety margins of lesions clinically apparent locally malignant, or malignant
Intervention: HIFU (Device)
Outcomes
Primary Outcomes
Complete excision of nonmelanoma skin cancers
Time Frame: Baseline
Determination the accuracy of HIFU to assess the margins of skin lesions and its safety margins to ensure complete elimination of lesions with maximum preservation of function and aesthetics
Secondary Outcomes
No secondary outcomes reported
Investigators
George Gamil Gergis
Doctor
Assiut University