Perinatal Outcomes in Patients With Suspicion of Preeclampsia and Elevated sFlt-1/PlGF Before Term: A Retrospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 190
- 试验地点
- 1
- 主要终点
- Hepatic enzyme abnormalities
研究概览
简要总结
Retrospective cohort study that evaluated 190 subjects admitted with diagnosis of hypertensive disorder of pregnancy, between 24 and 36 6/7 weeks, with an sFlt-1/PlGF index greater than or equal to 110. Data were collected on their clinical course prior to termination of pregnancy, using the last reported sFlt-1/PlGF ratio value to classify the population into four cohorts: values between 110-205, between 206 and 654, between 655 and 999 and greater than 1000.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of hypertensive disorder of pregnancy
- •Gestational age between 24 - 36 6/7
- •sFlt-1/PlGF > 110
排除标准
- •Gestational age below 23 6/7 weeks and above 37 weeks at the moment of admission.
- •Absence of sFLt-1/PlGF ratio result.
结局指标
主要结局
Hepatic enzyme abnormalities
时间窗: From the moment of admission up until discharge after delivery, average 5 to 10 days
Increase of liver enzyme to \> twice the upper limit of normal
Kidney injury
时间窗: From the moment of admission up until discharge after delivery, average 5 to 10 days
Creatinine level \> 1.1 Doubling of creatinine levels when others causes had been excluded
Growth restricted fetus
时间窗: From the moment of admission up until delivery, average 5 to 10 days
Fetal weight below 10th percentile and abnormal doppler Fetal weight below 3th percentile
HELLP Syndrome
时间窗: From the moment of admission up until discharge after delivery, average 5 to 10 days
Elevated liver enzymes Thrombocytopenia Hemolysis
Stillbirth
时间窗: From the moment of admission up until discharge after delivery, average 5 to 10 days
Intrauterine fetal demise
次要结局
未报告次要终点
研究者
Osvaldo A. Reyes T.
Head of the research deparment
Saint Thomas Hospital, Panama