Does cerebral hyperglycaemia lead to activation of the neurotoxic polyol pathway?

• Conditions: cerebral glucose metabolism; polyol pathway; postoperative cognitive dysfunction (POCD); hyperglycemia; neurocognitive; Cerebrospinal fluid (CSF); sorbitol; fructose; Montreal Cognitive Assessment (MoCA)

• Registration Number: NL-OMON27740
• Lead Sponsor: Amsterdam UMC - Location AMC / University Medical Center Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

•Spinal anaesthesia for elective surgery
•18 years and older

Exclusion Criteria

•Neurometabolic disorder

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The association between cerebral glucose concentration and cerebral sorbitol and fructose concentration. <br>

Secondary Outcome Measures

Name	Time	Method
?The correlation between plasma glucose levels with CSF glucose levels<br>?The correlation between cognitive function and cerebral glucose, sorbitol and fructose<br>?Differences in the above mentioned objectives between patients with low plasma glucose, high plasma glucose and DM-patients