Brain Activation in Response to Appetite Cues Pre- and Post- Bariatric Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Obesity
- Sponsor
- New York Obesity and Nutrition Research Center
- Enrollment
- 120
- Locations
- 2
- Primary Endpoint
- BOLD signal response to visual and auditory food cues
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
Utilizing fMRI, this study will examine changes in BOLD signal as a proxy measure of brain activation in response to highly palatable (high energy density [kcal/g]), less palatable and non-food stimuli in severely obese women pre, 1 month post and 3 months post undergoing bariatric surgery (in surgery patients) and at equivalent times for control groups in fed and fasted conditions at each time point.
Two surgical groups: (i) laparoscopic Roux-en-Y gastric bypass (RYGB) and (ii) gastric banding (GB) will be compared with two control groups: (i)those enrolled on a 3-month formula weight loss program or (ii) those who qualify, but do not undergo bariatric surgery, and receive no weight loss treatment.
Investigators
Dr. Allan Geliebter
Principal Investigator
New York Obesity and Nutrition Research Center
Eligibility Criteria
Inclusion Criteria
- •Age \> 18 and \< 65 years
- •BMI \> 40 and \< 50kg/m2
- •Right handed
- •Good comprehension of English
Exclusion Criteria
- •\> 5% weight fluctuation in the past 3 months
- •Presence of disease (including diabetes)
- •Pregnancy, lactation or planning to become pregnant in next 18mon
- •Smoking, or or recent (within past 12 month) smoking cessation
- •Consumption of \> 3 alcoholic beverages per day
- •Left handed
Outcomes
Primary Outcomes
BOLD signal response to visual and auditory food cues
Time Frame: pre-surgery, 1mo post and 3mo post surgery
BOLD signal changes in the brain in response to highly palatable (high energy density \[kcal/g\]), less palatable (low energy density)and non-food, stimuli in severely obese women pre-surgery, 1 month post-surgery and 3 months post bariatric surgery