Beneficial Effect of Xylose Consumption on Postprandial Hyperglycemia in Subjects With Normal Glucose Level and Impaired Fasting Glucose
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 主要终点
- Change of serum glucose levels
研究概览
简要总结
The present study determined the effect of Xylose consumption on postprandial hyperglycemia in normal (n=25) and hyperglycemic subjects (n=50).
详细描述
In this double-blind crossover designed study, Participants were randomly assigned to consume a sucrose drink (Control, sucrose 50g + deionized water 100g) or a sucrose drink additionally containing 5 g (Test 1, sucrose : xylose = 10:1), 3.33 g (Test 2, sucrose : xylose = 15:1) or 2.5 g (Test 3, sucrose : xylose = 20:1) of D-xylose with a week interval.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy subject or Impaired fasting glucose (fasting serum glucose between 100 and 125 mg/dL)
排除标准
- •history of taking an insulin-injection or oral hypoglycemic agents
- •evidence of alcohol abuse or alcoholism
- •pregnancy or breast feeding
- •chronic gastrointestinal disorder
- •seriously abnormal liver or renal function
- •an occupation at risk of death when hypoglycemia occurs
研究组 & 干预措施
Control group
sucrose drink (Control, sucrose 50g + deionized water 100g)
干预措施: Control (Dietary Supplement)
5 g xylose group
5 g xylose (Test 1, sucrose : xylose = 10:1),
干预措施: Test 1 (Dietary Supplement)
3.33 g xylose group
3.33 g xylose (Test 2, sucrose : xylose = 15:1)
干预措施: Test 2 (Dietary Supplement)
2.5 g xylose group
2.5 g xylose (Test 3, sucrose : xylose = 20:1)
干预措施: Test 3 (Dietary Supplement)
结局指标
主要结局
Change of serum glucose levels
时间窗: a week interval
次要结局
- Change of serum insulin levels(a week interval)
- Change of serum C-peptide levels(a week interval)
研究者
Jong Ho Lee
Department of Food and Nutrition
Yonsei University