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临床试验/NCT05222737
NCT05222737已完成2 期

Quantitave Assessment of Aggregatibacter Actinomycetemcomitans and Porphyromonas Gingivalis by Real -Time PCR Following Application of Diode Laser in Severe Periodontitis (A RANDIOMIZED CONTROLLED CLINICAL TRIAL)

Alexandria University1 个研究点 分布在 1 个国家目标入组 50 人开始时间: 2021年1月1日最近更新:
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适应症
干预措施
相关药物

试验速览

阶段
2 期
状态
已完成
入组人数
50
试验地点
1
主要终点
Quantitation of Aggrecatibacter .actinomycetemcomitans and porphyromonas gingivalis bacteria
研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

  1. Primary objective To measure the gingival crevicular levels of A.actinomycetemcomitans and P.gingivalis after intra-pocket application of diode laser in severe periodontitis (stage 3 grade C) patients.
  2. Secondary objective To compare the levels of the same microorganisms as in cases of diode laser therapy to those after conventional treatment with systemic antibiotic administration in severe periodontitis (stage 3 grade C) patients.
  3. to measure clinical parameters probing depth,attachment loss and mobility grade

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Double (Participant, Care Provider)

入排标准

年龄范围
15 Years 至 35 Years（Child, Adult）
性别
All
接受健康志愿者
是

入选标准

  • •Patients of both sexes having severe periodontitis (stage 3 grade C) with interdental clinical attachment loss (CAL) ≥
  • •Patients' age between 15 and 35 years old with rapid bone loss showed by radiograph.
  • •Systemically healthy patients.
  • •Radiographic bone loss extending to middle or apical third of root.
  • •Probing depth (PD) ≥ 6 mm.

排除标准

  • •Use of antibiotics during the last 3 months.
  • •Any systemic condition that might affect the study.
  • •Use of mouthwash containing antimicrobials during the previous 3 weeks.

研究组 & 干预措施

test group

Active Comparator

intra pocket diode laser application

干预措施: medency diode laser (Device)

control group

Active Comparator

antibiotic adminstration

干预措施: spirazole forte (Drug)

结局指标

主要结局

Quantitation of Aggrecatibacter .actinomycetemcomitans and porphyromonas gingivalis bacteria

时间窗: baseline

To measure the gingival crevicular levels of A.actinomycetemcomitans and P.gingivalis after intra-pocket application of diode laser in severe periodontitis(stage 3 grade C) patients

次要结局

  • comparing levels of bacteria between test and control groups(baseline)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

amira hafez

Resident at department of periodontolgy. Alexandria university

Alexandria University

研究点 (1)

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