Lymph Node Metastases and Arterial Ligation in Rectal Cancer Surgery

Completed

• Conditions: Lymph Node Metastases

• Registration Number: NCT03314961
• Lead Sponsor: Region Västmanland

Brief Summary

Lymph node status is of major prognostic importance in non-metastatic rectal cancer. For oncological reasons, central arterial ligation of the inferior mesenteric artery (IMA) is suggested. However, there is no conclusive evidence presented for this procedure.

This study aimed at investigating the localisation of lymph node metastases and the role of central versus peripheral arterial ligation of in rectal cancer specimens.

Detailed Description

Prospective population-based study of specimens from patients that underwent surgical resection for rectal cancer in Västmanland County, Sweden. Specimens were divided in 3 sections (A-C) and the total amount of lymph nodes and the location of lymph node metastases were analysed.

Multivariate analysis was used to explore the relationship between lymph node counts and age, gender, BMI, preoperative oncological treatment, type of surgery, tumour stage, vessel and specimen length.

Study Timeline

• Study Start: 2012-01
• Primary Completion: 2016-12
• Study Completion: 2016-12
• Status Verified: 2017-10
• Study First Submitted: 2017-10-16
• Study First Submitted QC: 2017-10-16
• Last Update Submitted: 2017-10-16
• Study First Posted: 2017-10-19
• Last Update Posted: 2017-10-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 151

Inclusion Criteria

• All patients that were curatively operated for rectal cancer in Västmanlands county 2012-2016.

Exclusion Criteria

• Patients that were not operated or had another type of cancer.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Lymph node metastases in rectal cancer	2012-2016	Analyses of number and location of lymph node metastases in rectal cancer