Comparison of inflammatory markers in low pressure pneumoperitoneum with deep neuromuscular block versus standard pressure pneumoperitoneum among patients undergoing laparoscopic cholecystectomy for gallstone disease: A Randomized Control Trial.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Difference in inflammatory marker levels between the 2 groups i.e. IL-6, IL-1,IL-17,TNF alpha, WBC, ESR, CRP,Albumin, cortisol, Hb, platelet count
研究概览
简要总结
There is a dearth of literature regarding inflammatory markers in patients undergoing laparoscopic surgery with low-pressure
pneumoperitoneum in combination with deep neuromuscular blockade. A few studies have explored the correlation between these markers and postoperative pain outcomes. Many patients still experience pain despite undergoing minimally invasive surgery. The utilization of objective markers can aid in understanding the reasons behind pain. Consequently, this study aims to compare the levels of
inflammatory markers in patients undergoing laparoscopic cholecystectomy with low-pressure pneumoperitoneum and deep neuromuscular blockade (NMB) to those undergoing laparoscopic cholecystectomy using standard-pressure pneumoperitoneum with moderate NMB.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •BMI less than 30 ASA I,II Patient able to follow instructions.
排除标准
- •Any prior inflammatory conditions like Arthritis, Chronic skin diseases, IBD Pregnancy.
结局指标
主要结局
Difference in inflammatory marker levels between the 2 groups i.e. IL-6, IL-1,IL-17,TNF alpha, WBC, ESR, CRP,Albumin, cortisol, Hb, platelet count
时间窗: baseline, 24 hours post surgery
次要结局
- Pain scores by NPRS(Incidence of Complications)
研究者
Ankita Singh
All India Institute of Medical Sciences, Delhi