Outcome of Cardiac Arrest Patients Following Guidelines Implementation Over the Years

Recruiting

• Conditions: Cardiac Arrest

• Registration Number: NCT06608771
• Lead Sponsor: Mauro Panigada

Brief Summary

The study aims to evaluate the level of local implementation of the new interventions introduced by the guidelines for post-cardiac arrest management and their impact on the survival of patients resuscitated from cardiac arrest and admitted to intensive care over a 14-year period. During this time period, the European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM) introduced three new guidelines for post-cardiac arrest management, each five years apart: the 2010, 2015, and 2021 guidelines.

Detailed Description

This study is a retrospective multicenter cohort observational study (two centers involved: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and Fondazione IRCCS San Gerardo dei Tintori).

All patients admitted to the Intensive Care Units (ICU) of the hospitals involved in the study from January 1, 2011, to May 30, 2024, following cardiac arrest of any etiology, who meet the inclusion and exclusion criteria, will be enrolled.

Study Timeline

• Study Start: 2024-07-26
• Study First Submitted: 2024-08-08
• Status Verified: 2024-09
• Study First Submitted QC: 2024-09-20
• Last Update Submitted: 2024-09-20
• Study First Posted: 2024-09-23
• Last Update Posted: 2024-09-23
• Primary Completion: 2025-12-31
• Study Completion: 2026-03-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 693

Inclusion Criteria

• Patients resuscitated from cardiac arrest and admitted to intensive care unit
• Age ≥ 18 years
• Out-of-hospital and in-hospital cardiac arrest
• Cardiac arrest of any etiology

Exclusion Criteria

• Pediatric patients (<18 years)
• Patients not admitted to one of the aforementioned intensive care units.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Intensive Care Unit (ICU) Survival	From cardiac arrest date to ICU discharge or death, up to 90 days	To evaluate ICU survival for patients resuscitated from cardiac arrest
Neurological recovery at ICU discharge	From cardiac arrest date to ICU discharge or death, up to 90 days	ICU Survival with Cerebral Performance Category (CPC) score of 1 or 2

Secondary Outcome Measures

Name	Time	Method
Hospital discharge status	From cardiac arrest date to hospital discharge or death, up to 180 days	To evaluate hospital survival for patients resuscitated from cardiac arrest

Trial Locations

Locations (2)

Fondazione IRCCS San Gerardo dei Tintori; 🇮🇹 Monza, Monza E Brianza, Italy

IRCCS Ca' Granda Ospedale Maggiore Policlinico; 🇮🇹 Milan, Italy