Evaluation of efficacy of platelet rich plasma (PRP) and sonicated platelet lysate (SPL) in the management of temporomandibular joint disorders – a randomized controlled clinical trial

Temporomandibular Joint Disorders (TMD) are musculoskeletal conditions causing pain, joint dysfunction, and impaired jaw movement. Traditional treatments offer only temporary relief and lack regenerative potential. This randomized controlled clinical trial aims to compare the efficacy of Platelet-Rich Plasma (PRP) and Sonicated Platelet Lysate (SPL) in improving pain, jaw function, and joint structure in patients with TMD.

A total of 34 patients not responding to conservative therapy will be randomly assigned to receive either PRP or SPL intra-articular injection. The primary outcomes include pain relief (Visual Analogue Scale) and functional improvement (mouth opening, jaw deviation, joint sounds). Secondary outcomes include MRI-based morphological changes and quality of life assessments.

Clinical assessment will be done preoperatively and at 7 days, 1 month, 3 months, 6 months, and 12 months postoperatively. Radiographic assessment using MRI will be conducted preoperatively and at 12 months. Quality of life will be assessed at 6 and 12 months post-treatment. Both participants and outcome assessors will be blinded to the group assignments to ensure objective evaluation.

The study aims to identify the more effective biologic therapy and promote a minimally invasive, evidence-based approach for TMD management.