Effect of shift work on human health and metabolism; a preliminary study

Not Applicable

Completed

• Conditions: Gut disorders due to disruption of sleep schedule; Oral and Gastrointestinal - Normal oral and gastrointestinal development and function; Metabolic and Endocrine - Normal metabolism and endocrine development and function

• Registration Number: ACTRN12615000208505
• Lead Sponsor: The New Zealand Institute for Plant and Food Research

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-03-04
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Adult (18-65 years) with a BMI between 18.5-29 will be considered.
For the purpose of this study, shift workers are defined as people who have undertaken shift work duties for at least 1 year on permanent night or rotating shifts with at least 2 nights per week. Night shift is defined as at least 3 hours work between midnight and 5am.
Non-shift workers are defined as people who are on permanent work schedules during the day time with no shift work history over the last 1 year and do not suffer from sleep disruption on a regular basis (no more than 1 sleep disruption episode during one week).

Exclusion Criteria

Candidates who suffer from chronic disease (cancer, diabetes, cardiovascular or gastrointestinal disorders, neurological conditions (e.g. multiple sclerosis, spinal cord injury, and stroke).
Women who are pregnant or breastfeeding will also be excluded.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Quantification of blood and urinary chemical metabolites by liquid chromatography-mass spectrometry [On the Day 8; after 8 hour fasting ];Changes in faecal bacteria by next generation gene sequencing[On the Day 8; after 8 hour fasting];Quantification of circadian markers in blood by gene expression[On the Day 8; after 8 hour fasting]

Secondary Outcome Measures

Name	Time	Method
Assessing sleep quality by 7 day sleep log used by Sleep Wake Research Institute/Massey University[Each day during the observational period (7 days)];Dietary intake using 3 day Diet record used by Plant and Food Research[During the 3 days (i.e. days 5,6, and 7) before the sample donation day];Gut health assessment using a gut health questionnaire used by Plant and Food Research designed by Plant and Food Research with input from external collaborators.[At the initial screening]