Influence of Anaesthesia Type on Multiple Sclerosis Relapse

Completed

• Conditions: Multiple Sclerosis
• Interventions: Procedure: Neuraxial anaesthesia; Procedure: General anaesthesia

• Registration Number: NCT06526130
• Lead Sponsor: Varazdin General Hospital

Brief Summary

The influence of anesthesia on the course of multiple sclerosis is poorly investigated and the literature is limited.

The aim of this study is to investigate multiple sclerosis relapse after different types of anesthesia.

Detailed Description

The influence of anesthesia on the course of multiple sclerosis is poorly investigated and the literature is limited. A possible relapse after neuraxial anesthesia, it is believed to be associated with local anesthetic's toxicity and concentration.

The aim of this study is to investigate multiple sclerosis relapse after different types of anesthesia.

Study Timeline

• Study Start: 2012-01-01
• Primary Completion: 2022-12-31
• Study Completion: 2024-05-16
• Status Verified: 2024-07
• Study First Submitted: 2024-07-23
• Study First Submitted QC: 2024-07-23
• Last Update Submitted: 2024-07-26
• Study First Posted: 2024-07-29
• Last Update Posted: 2024-07-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 56

Inclusion Criteria

• multiple sclerosis
• surgical procedure under general anaesthesia
• surgical procedure under neuraxial anaesthesia

Exclusion Criteria

• patients (medical records) with incomplete data

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Neuraxial anaesthesia	Neuraxial anaesthesia	Neuraxial anesthesia was administered using spinal or epidural injections of local anesthetic with or without opioid.
General anaesthesia	General anaesthesia	Intravenous or volatile general anesthesia was preformed with different type of airway management (endotracheal tube, laryngeal mask and bag mask ventilation)

Primary Outcome Measures

Name	Time	Method
Multiple sclerosis relapse after 12 months	12 months	Overall incidence of multiple sclerosis relapse after 12 months after anaesthesia
Multiple sclerosis relapse after 1 month	1 month	Overall incidence of multiple sclerosis relapse after 1 month after anaesthesia
Multiple sclerosis relapse after 6 months	6 months	Overall incidence of multiple sclerosis relapse after 6 months after anaesthesia
Multiple sclerosis relapse after 3 months	3 months	Overall incidence of multiple sclerosis relapse after 3 months after anaesthesia