Hemodynamic Testing Strategies to Assess Pulmonary Hypertension and Right Ventricular Function in Heart Failure Patients
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 74
- 试验地点
- 1
- 主要终点
- right ventricular end systolic elastance
研究概览
简要总结
The goal of this observational study is to learn about heart function and high lung blood pressure in patients with heart failure. The main question[s] it aims to answer are whether we can improve the ability to predict patients who will have complications after they receive treatment including heart transplant and left ventricular assist devices.
详细描述
Prospective cohort study of patients with heart failure with reduced ejection fraction that are referred for diagnostic right heart catheterization as part of their evaluation for candidacy for advanced heart failure therapies.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults age 18 years or older
- •Heart failure with reduced ejection fraction (<40%)
- •referred for RHC at our centre for evaluation of candidacy for advanced HF therapies.
排除标准
- •Severe valvular or complex congenital heart disease Short-term mechanical circulatory support for progressive cardiogenic shock (e.g. extracorporeal membrane oxygenation) Acute coronary syndrome or revascularization occurred within 7 days prior to the RHC.
- •Pregnant or breast-feeding Known hypersensitivity to sodium nitroprusside Advanced liver dysfunction Reduced capacity or inability to provide informed consent
结局指标
主要结局
right ventricular end systolic elastance
时间窗: First study 1 day visit
Hemodynamic measurement
pulmonary arterial elastance
时间窗: First study 1 day visit
hemodynamic measurement
Mean pulmonary artery pressure
时间窗: First study 1 day visit
Hemodynamic measurement
次要结局
- Right ventricular failure after heart transplant(1 year)
- Right ventricular failure after left ventricular assist device(1 year)