Stereotactic radiosurgery (SRS) versus whole-brain radiotherapy (WBRT) in patients with 4-10 brain metastases

Phase 2

• Conditions: C79.3; Secondary malignant neoplasm of brain and cerebral meninges

• Registration Number: DRKS00014694
• Lead Sponsor: Klinik und Poliklinik für Strahlentherapie und Radioonkologie; LMU Klinikum der Universität München

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-05-25
• Study Completion: 2021-07-01
• Results First Posted: 2023-06-15
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Patient must be able to comply with the study protocol and provide informed consent
- Age =18 years, male and female
- Patients with 4-10 brain metastases of any malignancy except lymphoma/germinoma/SCLC
- Brain metastases of 0.4-2.5 cm extent
- GPA scores 0-3

Exclusion Criteria

- Patients without legal capacity or unable to understand the nature, significance and consequences of the study
- Simultaneous participation in other interventional trials which could interfere with this trial and/or participation before the end of a required restriction period
- Pregnancy
- Cerebral lymphomas or metastases of germinoma or SCLC
- Meningiosis carcinomatosa
- Previous whole brain irradiation
- Inability to undergo an MRI examination (e. g. pacemaker)

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Overallsurvival

Secondary Outcome Measures

Name	Time	Method
Intercraniell control; acute and late toxicity