A Double-Blind Randomised Placebo-Controlled Trial Assessing the Effect of Peri-Operative Intravenous Lignocaine and Post-Operative Lignocaine Neurovascular Plane Infusion on Natural Killer Cell Function in Laparoscopic Colorectal Cancer Surgery

Hunter New England Local Health District0 个研究点目标入组 107 人开始时间: 2018年5月4日最近更新: 2023年11月20日

研究概览

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•All patients with colorectal cancer undergoing elective or semi-elective laparoscopic colon resection at the John Hunter Hospital and Newcastle Private Hospital

•a. are under 18 years of age, or
•b. refuse or are unable to give written informed consent to participate in the study, or
•c. have had previous abdominal surgery where there is a significant chance of the procedure not being able to be completed in a laparoscopic manner, based in the clinical judgement of the operating surgeon, or
•d. have severe renal impairment or
•e. receive an epidural, spinal or other neuroaxial anaesthetic as determined by the Anaesthetist on day of surgery, or
•f. Have a planned stoma formation or
•a. Have received neoadjuvant chemo-radiotherapy or have been on immunosuppressive agents in the preceding 8 weeks including glucocorticoids (not including inhaled steroids), antimetabolites, cytostatics (eg platinum compounds), antimetabolites (eg methotrexate, mercaptopurine, azathioprine, 5FU, anthracyclines, cytotoxic antibiotics eg bleomycin) , TNF bindng proteins (eg infliximab), drugs acting on immunophilins or
•b. Have known stage 4 colorectal cancer disease
•c. have known immunological disease including leukaemia or
•d. have known allergy or adverse reaction to lignocaine or opioid drugs or
•e. pregnant or lactating or
•f. have a history of arrhythmia or long QT syndrome associated with the drugs used in this trial, or
•g. Are taking regular opiate narcotics pre-operatively

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