Water Load Test Value for Hyponatremia

Completed

• Conditions: SIAD - Syndrome of Inappropriate Antidiuresis; Hyponatremia
• Interventions: Procedure: Acute water load test

• Registration Number: NCT04256499
• Lead Sponsor: European Georges Pompidou Hospital

Brief Summary

Acute water load test has been using to diagnose renal ability to excrete water for decades. Latest recommendations for the diagnosis of hyponatremia do not recommend performing such a test. The investigators aim at, retrospectively, study the value of acute water load test in patients suffering from a syndrome of inappropriate antidiuresis.

Detailed Description

Not available

Study Timeline

• Study Start: 2001-01-01
• Primary Completion: 2019-12-31
• Study Completion: 2019-12-31
• Status Verified: 2020-02
• Study First Submitted: 2020-02-03
• Study First Submitted QC: 2020-02-04
• Last Update Submitted: 2020-02-04
• Study First Posted: 2020-02-05
• Last Update Posted: 2020-02-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• ≥ 18 years old at the time of the test
• affiliated to a social insurance system
• water load test performed at the Renal and Metabolic Diseases Unit of the European George Pompidou Hospital, AP-HP, Paris, France
• between 01/01/2001 and 12/31/2019

Exclusion Criteria

• hypernatremia and/or polyuria-polydipsia (diabetes insipidus)
• hyponatremia due to a tea and toast syndrome and/or a beer potomania
• hyponatremia due to a high (or normal) osmolality related to diabetes mellitus, hyperproteinemia and/or intoxication
• chronic kidney disease with an estimated glomerular filtration rate (eGFR) by the MDRD formula <60 mL/min/1.73m2
• hyponatremia related to thiazides
• hyponatremia related to an hypovolemic status
• syndrome of inappropriate antidiuresis related to an endocrine disorder (such as hypothyroidism or adrenal insufficiency)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Water load test	Acute water load test	Patients experiencing a syndrome of inappropriate antidiuresis who had an acute water load test
Control group	Acute water load test	Patients who had an acute water load test and who did not experience any water homeostasis anomalies

Primary Outcome Measures

Name	Time	Method
Natremia	any time after water load test from hour 2 to hour 6	Plasma sodium concentration (abnormal if \<135mM)

Secondary Outcome Measures

Name	Time	Method
Plasma osmolality	any time after water load test from hour 2 to hour 6	Plasma osmolality (abnormal if \<280mOsm/kgH2O)
Excretion of water load	after water load test from hour 0 to hour 6	Ratio between the excreted water (in urine) volume and the ingested one
Urine osmolality	any time after water load test from hour 2 to hour 6	Minimum urine osmolality reached

Trial Locations

Locations (1)

European Georges Pompidou Hospital, APHP; 🇫🇷 Paris, France