Pericapsular Nerve Group (PENG) Block Combined With Periarticular Multimodal Drug Injection (PMDI) Versus Isolated PMDI for Pain Management After Total Hip Arthroplasty: a Randomized Controlled Trial

Not Applicable

• Conditions: Total Hip Arthroplasty, Postoperative Pain
• Interventions: Procedure: isolated periarticular multimodal drug injection (PMDI); Procedure: Pericapsular nerve group(PENG) block combined with periarticular multimodal drug injection (PMDI)

• Registration Number: NCT05320913
• Lead Sponsor: Yonsei University

Brief Summary

Adequate pain control after total hip arthroplasty is crucial for early ambulation and patient satisfaction. However, there is no consensus about optimal pain control after post operation. In general, the periarticular multimodal durg injection block has been done for pain control in primary total hip arthroplasty. The pericapsular nerve group (PENG) block has been recently introduced a new technique for blockade of the articular branches of the femoral, obturator and accessory obturator nerves. PENG block is possible to provide sufficient analgesia and preserve lower limb muscle strength. The investigators will compare PENG and PMDI block with isolated PMDI block in patients undergoing total hip arthroplasty.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-04-03
• Study Start: 2022-04-04
• Study First Submitted QC: 2022-04-08
• Study First Posted: 2022-04-11
• Status Verified: 2022-05
• Last Update Submitted: 2022-05-02
• Last Update Posted: 2022-05-03
• Primary Completion: 2023-12-13
• Study Completion: 2023-12-13

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 58

Inclusion Criteria

1. Patients aged 19 years old or older, with American Society of Anesthesiologists Physical Status 1-3, and scheduled for elective unilateral total hip arthroplasty

Exclusion Criteria

1. Allergy or intolerance to any of the drugs used in the study
2. Hepatic or renal insufficiency
3. Opioid dependency
4. Coagulopathy
5. Pre-existing neurologic or anatomic deficits in the lower extremities
6. Severe psychiatric illness

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
isolated periarticular multimodal drug injection (PMDI)	isolated periarticular multimodal drug injection (PMDI)	Arm Description: Participants receiving isolated periarticular multimodal drug injection (PMDI)
Pericapsular nerve group(PENG) block combined with periarticular multimodal drug injection (PMDI)	Pericapsular nerve group(PENG) block combined with periarticular multimodal drug injection (PMDI)	Participants receiving pericapsular nerve group(PENG) block combined with periarticular multimodal drug injection (PMDI)

Primary Outcome Measures

Name	Time	Method
Numeric rating scale pain score	at 24 hours postoperatively	Pain intensity at rest evaluated by an 11-point numeric rating scale (NRS: 0 = no pain, 10 = worst imaginable pain) at 24 hours postoperatively

Secondary Outcome Measures

Name	Time	Method
Pain score measured at 6 hours postoperatively and 48 hours postoperatively	Pain score measured at 6 hours postoperatively and 48 hours postoperatively	Pain intensity at rest evaluated by an 11-point numeric rating scale (NRS: 0 = no pain, 10 = worst imaginable pain) at 6 hours postoperatively and 48h postoperatively

Trial Locations

Locations (1)

Yonsei University Health System, Severance Hospital; 🇰🇷 Seoul, Korea, Republic of