Lyon PJI Retrospective Cohort Study

• Conditions: Bone and Joint Infection
• Interventions: Other: PJI

• Registration Number: NCT04722926
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Bone and joint infections (BJI), although infrequent (prevalence of 70 per 100,000 in France), have a significant economic and clinical impact. Between 2008 and 2013, the prevalence of BJI increased and infections involving joint prosthesis (PJI) represent a third of BJI in France. They are most often post-operative and more expensive than native IOAs.

This study aims to describe PJI and understand the failure mechanisms of PJI in order to improve their management.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-01-15
• Study First Submitted QC: 2021-01-22
• Study First Posted: 2021-01-25
• Status Verified: 2022-01
• Study Start: 2022-01-10
• Last Update Submitted: 2022-01-19
• Last Update Posted: 2022-01-20
• Primary Completion: 2022-11-01
• Study Completion: 2024-03-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

• patients having had a PJI between 2018 and 2020

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Exclusion Criteria

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
PJI	PJI	Patients having had a PJI

Primary Outcome Measures

Name	Time	Method
Description of type of prosthesis PJI	between 2018 and 2020	number of prosthesis
Description of patients having had a PJI	between 2018 and 2020	type of patients: age
description of antibiotic treatment	between 2018 and 2020	duration of antibiotic treatment
rate of PJI	between 2018 and 2020	proportion of PJI among all BJI
Description of PJI	between 2018 and 2020	acute/chronic
description of antibiotic used	between 2018 and 2020	type of antibiotic : name
description of surgical treatment	between 2018 and 2020	type of surgery: 1-step exchange, 2- step exchange, DAIR
Description of comorbidities of patients having had a PJI	between 2018 and 2020	type of comorbidities..
rate of bacteria	between 2018 and 2020	epidemiologic description of PJI

Secondary Outcome Measures

Name	Time	Method
rate of failure	between 2018 and 2020	proportion of patients having a failure
description of the failure	between 2018 and 2020	type of failure : persistence or surinfection and management of failure

Trial Locations

Locations (1)

Hospices Civils de Lyon; 🇫🇷 Lyon, France