Evaluation of the effectiveness of systemic Echinacea on clinical indices of erosive oral lichen planus
- Conditions
- Erosive oral lichen planus.Lichen planus
- Registration Number
- IRCT20200223046591N1
- Lead Sponsor
- Esfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 64
Patients sufering from erosive oral lichen planus refered to isfahan dental school department of oral medicine whose lesions are clinically and pathologically confirmed according to WHO criteria
Certaining of the patient's cooperation and consent
presence of at least one lichen planus lesion in oral cavity
according to modified Thongprasom criteria the clinical score must be more than 1
patients attended another clinical trial in past 3 months
pregnancy and lactation
presence of lichenoid reactions
presence of extraoral lesions
use of systemic steroid drugs, analgesics, immunomodulation drugs, NSAIDs a week before trial
presence of other lesions in oral cavity
history of asthma and allergy
patients suffering from systemic conditions such as diabetes, TB, high blood pressure, life threatening diseases and cancer
patients suffering from ulcerative colitis, entrogastric diseases, crohns syndrome, behjet`s syndrome, intensive anemia, rheumatoid arthritis, lupus, multiple sclerosis, collagen disorders, leukosis and AIDS
history of organ transplantation
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method esion size. Timepoint: At baseline(before intervention),10,25 and 35 days after using Echinacea tablets. Method of measurement: graph paper and ruler.;Pain level. Timepoint: At baseline(before intervention),10,25 and 35 days after using Echinacea tablets. Method of measurement: Visual Analogue Scale index.
- Secondary Outcome Measures
Name Time Method Duration of lesion healing. Timepoint: At baseline(before intervention),10,25 and 35 days after using Echinacea tablets. Method of measurement: day.;Duration of pain relief. Timepoint: At baseline(before intervention),10,25 and 35 days after using Echinacea tablets. Method of measurement: day.