Motor Training and White Matter in Multiple Sclerosis (MS)
Not Applicable
Terminated
- Conditions
- Multiple Sclerosis
- Registration Number
- NCT01279655
- Lead Sponsor
- Hasselt University
- Brief Summary
In the current study the researchers will firstly investigate whether a bimanual coordination training protocol (20 min/day, for 8 consecutive weeks) correlates with changes in white matter architecture and improved upper-limb functionality in patients with multiple sclerosis. Secondly, the researchers predict that motor learning is more efficient when it is combined with anodal transcranial direct current (tDCS) stimulation on the left primary motor cortex.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
- Expanded Disability Status Scale (EDSS) scores between 2 and 6.5
- Stable MS (no relapse during the last 3 months before study onset)
- age: between 18 and 68 years
Exclusion Criteria
- Patients with other pathologies associated with peripheral and/or central sensory dysfunction or under psychotropic or antiepileptic medication.
- Standard TMS/tDCS and MRI exclusion criteria (safety questionnaires)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Change in White Matter Baseline, immediately after and 3 weeks after the intervention Diffusion Tensor Imaging (DTI) T1 structural scan Fluid-attenuated inversion recovery Scan (FLAIR) Magnetization Transfer Imaging (MTI)
- Secondary Outcome Measures
Name Time Method Change in Quality of Life Baseline, immediately after and 3 weeks after the intervention Questionnaire
Blood sample After the end of the study BDNF Genotyping
Trial Locations
- Locations (1)
Hasselt University (BIOMED)
🇧🇪Diepenbeek, Limburg, Belgium
Hasselt University (BIOMED)🇧🇪Diepenbeek, Limburg, Belgium