Prevention Interventions for Opioid Misuse
- Conditions
- Opioid Use
- Interventions
- Behavioral: Brief intervention (BI)Behavioral: Enhanced Usual Care (EUC)Behavioral: Portal
- Registration Number
- NCT04550715
- Lead Sponsor
- University of Michigan
- Brief Summary
The purpose of the study is to develop and test innovative interventions to prevent the development of opioid misuse and opioid use disorders among older adolescents and young adults (AYA; ages 16-30) who use opioids, which will be initiated from a health care visit in the emergency department and extended post discharge via a telehealth approach. This study will have significant impact by identifying optimal, cost-effective opioid prevention strategies to sustain outcomes among AYAs.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 1155
- Aged 16-30 years
- Seeking care in Michigan Medicine emergency department (ED)
- Ability to read/comprehend and communicate in English
- Medically & cognitively able to provide consent or assent
- Prescription opioid use plus >=1 other risk factor (misuse positive for marijuana, other illicit drugs, other prescription drug misuse; binge drinking; depression or suicidality) or opioid misuse [prescription opioid misuse or illicit opioid use (e.g., heroin, fentanyl)]
- Presenting with acute sexual assault, acute suicidality or a current cancer diagnosis/are currently receiving cancer treatment
- Current pregnancy at baseline
- History of injection drug use within last 12 months
- High risk for opioid use disorder
- Enrolled in Aim 1
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- FACTORIAL
- Arm && Interventions
Group Intervention Description Brief intervention (BI) then Portal Brief intervention (BI) The BI will be delivered at intake and the portal will occur for 4 weeks starting at intake. Brief intervention (BI) then Enhanced Usual Care (EUC) Enhanced Usual Care (EUC) The BI will be delivered at intake and EUC will be added 4 weeks later. Enhanced Usual Care (EUC) then EUC Enhanced Usual Care (EUC) EUC will be delivered at intake and delivered again 4 weeks later. Brief intervention (BI) then Portal Portal The BI will be delivered at intake and the portal will occur for 4 weeks starting at intake. Brief intervention (BI) then Enhanced Usual Care (EUC) Brief intervention (BI) The BI will be delivered at intake and EUC will be added 4 weeks later. Enhanced Usual Care (EUC) then Portal Portal EUC will be delivered at intake and the portal will occur for 4 weeks starting at intake. Enhanced Usual Care (EUC) then Portal Enhanced Usual Care (EUC) EUC will be delivered at intake and the portal will occur for 4 weeks starting at intake.
- Primary Outcome Measures
Name Time Method Change in opioid misuse 3, 6, and 12 months Alcohol Smoking and Substance Involvement Screening Test severity score (prescription opioids/heroin, scores range 0-27 per subscale, higher score indicates worse outcomes)
- Secondary Outcome Measures
Name Time Method Change in overdose risk behaviors 3, 6, and 12 months Opioid-related risk behaviors (score ranges from 0-32, higher score indicates worse outcomes)
Change in days of opioid misuse 3, 6, and 12 months Addiction Severity Index (modified; score ranges from 0-30, higher score indicates worse outcomes)
Change in substance use consequences 3, 6, and 12 months Adapted alcohol, cannabis, and/or opioid-related consequences (total, higher score indicates worse outcomes)
Change in other drug and alcohol use 3, 6, and 12 months Substance use index (based on frequency measures, higher scores indicate worse outcome)
Change in impaired driving 3, 6, and 12 months Adapted items from Young Adult Driving Questionnaire (5 items; score ranges from 0-30; higher score indicates worse outcome)
Trial Locations
- Locations (1)
University of Michigan
🇺🇸Ann Arbor, Michigan, United States