Health Status Factors Predicting Responses to Long-Term Training: Effects of 16-Week High-Intensity Interval Training on Pre-Hypertensive Subjects
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Universidad Santo Tomas
- Enrollment
- 142
- Locations
- 1
- Primary Endpoint
- Change from Baseline in systolic blood pressure and diastolic blood pressure
Study Overview
Brief Summary
Despite exercise training decrease blood pressure in 'average' terms, there is a wide interindividual variability after exercise training, being yet unknown what mode of exercise (e.g. endurance, strength, concurrent, or high intensity interval training) produce more/less non-responder (NR) prevalence (i.e., percentage of subjects who experienced a non-change/worsened response after training in some outcome).
Detailed Description
Despite exercise training decrease blood pressure in 'average' terms, there is a wide interindividual variability after exercise training, being yet unknown what mode of exercise (e.g. endurance, strength, concurrent, or high intensity interval training) produce more/less non-responder (NR) prevalence (i.e., percentage of subjects who experienced a non-change/worsened response after training in some outcome).
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- Single (Investigator)
Eligibility Criteria
- Ages
- 20 Years to 40 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Written informed consent;
- •Interested in improving health and fitness;
- •Systolic blood pressure > 120 mmHg and < 140 mmHg, and/or DBP ≥ 80 and < 90 mmHg according with standard classification;
- •No drug therapy during the previous 3 months;
- •Body mass index (BMI) 25 and 35 kg/m2); (c) physically inactive (according to the International Physical Activity Questionnaire previously validated in Chilean population)
- •Normal /mild altered lipid profile (total cholesterol [TC] ~200 and ≤250 mg/dL, low-density lipids [LDL-C] ~140 mg/dL and ≤200 mg/dL, high-density lipids [HDL-C] ≥20 and ~40 mg/dL, triglycerides ~150 and ≤250 mg/dL) according with standard classification.
Exclusion Criteria
- •Cardiovascular contraindications to exercise histories of stroke;
- •Asthma and chronic obstructive pulmonary disease;
- •Musculoskeletal disorder such as low back pain;
- •Smokers in the last 3 months were not included in the study.
Arms & Interventions
High Intensity Interval Training
Cycling on cycle ergometers (OXFORDTM, model BE2601, OXOFORD Inc, Santiago, Chile) for 1 min at a subjective intensity of 8-10 points of the modified Borg scale of 1-10 points, and interspersed by inactive (without movement over the bicycle) of 2 minutes as recovery period.
Intervention: High Intensity Interval Training (Behavioral)
Control group
Pre-hypertensive group was compared with healthy groups in the 2 manin variables systolic/diastolic blood pressure, as well as in other co-variables in pre-post changes. Thus, after the training intervention, and following the R and NR classification, we will compare the NR prevalence between both Pre-hypertensive and Healthy group.
Intervention: Control group (Behavioral)
Outcomes
Primary Outcomes
Change from Baseline in systolic blood pressure and diastolic blood pressure
Time Frame: Baseline and 16 weeks immediately after the interventions ends
After this, we calculated the delta changes in both variables and classified to all subjects in responders (R) and non-responders (NR) to decrease systolic or diastolic blood pressure.
Secondary Outcomes
- Change from Baseline in waist circumference(Baseline and 16 weeks immediately after the interventions ends)
- Change from Baseline in fat mass(Baseline and 16 weeks immediately after the interventions ends)
- Change from Baseline in body mass index(Baseline and 16 weeks immediately after the interventions ends)
- Change from Baseline in body mass(Baseline and 16 weeks immediately after the interventions ends)
- Change from Baseline in one maximum repetition strength test of leg-extension exercise(Baseline and 16 weeks immediately after the interventions ends)
- Change from Baseline in heart rate at rest(Baseline and 16 weeks immediately after the interventions ends)
- Change from Baseline in fasting glucose(Baseline and 16 weeks immediately after the interventions ends)
- Change from Baseline in lipids(Baseline and 16 weeks immediately after the interventions ends)