High-Intensity Interval Training on Pre-Hypertensive Subjects

Not Applicable

Completed

• Conditions: Hypertension; Metabolism Disorder

• Registration Number: NCT03000140
• Lead Sponsor: Universidad Santo Tomas

Brief Summary

Despite exercise training decrease blood pressure in 'average' terms, there is a wide interindividual variability after exercise training, being yet unknown what mode of exercise (e.g. endurance, strength, concurrent, or high intensity interval training) produce more/less non-responder (NR) prevalence (i.e., percentage of subjects who experienced a non-change/worsened response after training in some outcome).

Detailed Description

Despite exercise training decrease blood pressure in 'average' terms, there is a wide interindividual variability after exercise training, being yet unknown what mode of exercise (e.g. endurance, strength, concurrent, or high intensity interval training) produce more/less non-responder (NR) prevalence (i.e., percentage of subjects who experienced a non-change/worsened response after training in some outcome).

Study Timeline

• Study Start: 2015-03
• Primary Completion: 2016-12
• Study First Submitted: 2016-12-17
• Study First Submitted QC: 2016-12-17
• Study First Posted: 2016-12-21
• Study Completion: 2017-02
• Status Verified: 2018-10
• Last Update Submitted: 2018-10-10
• Last Update Posted: 2018-10-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 142

Inclusion Criteria

• Written informed consent;
• Interested in improving health and fitness;
• Systolic blood pressure > 120 mmHg and < 140 mmHg, and/or DBP ≥ 80 and < 90 mmHg according with standard classification;
• No drug therapy during the previous 3 months;
• Body mass index (BMI) 25 and 35 kg/m2); (c) physically inactive (according to the International Physical Activity Questionnaire previously validated in Chilean population)
• Normal /mild altered lipid profile (total cholesterol [TC] ~200 and ≤250 mg/dL, low-density lipids [LDL-C] ~140 mg/dL and ≤200 mg/dL, high-density lipids [HDL-C] ≥20 and ~40 mg/dL, triglycerides ~150 and ≤250 mg/dL) according with standard classification.

Exclusion Criteria

• Cardiovascular contraindications to exercise histories of stroke;
• Asthma and chronic obstructive pulmonary disease;
• Musculoskeletal disorder such as low back pain;
• Smokers in the last 3 months were not included in the study.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Change from Baseline in systolic blood pressure and diastolic blood pressure	Baseline and 16 weeks immediately after the interventions ends	After this, we calculated the delta changes in both variables and classified to all subjects in responders (R) and non-responders (NR) to decrease systolic or diastolic blood pressure.

Secondary Outcome Measures

Name	Time	Method
Change from Baseline in waist circumference	Baseline and 16 weeks immediately after the interventions ends
Change from Baseline in fat mass	Baseline and 16 weeks immediately after the interventions ends
Change from Baseline in body mass index	Baseline and 16 weeks immediately after the interventions ends	BMI will be calculated as the body weight in kilograms divided by the square of the height in meters.
Change from Baseline in body mass	Baseline and 16 weeks immediately after the interventions ends
Change from Baseline in one maximum repetition strength test of leg-extension exercise	Baseline and 16 weeks immediately after the interventions ends
Change from Baseline in heart rate at rest	Baseline and 16 weeks immediately after the interventions ends	Baseline and 16 weeks immediately after the interventions ends
Change from Baseline in fasting glucose	Baseline and 16 weeks immediately after the interventions ends
Change from Baseline in lipids	Baseline and 16 weeks immediately after the interventions ends	Lipid profile (low-density cholesterol, total cholesterol, high-density cholesterol and triglycerides)

Trial Locations

Locations (1)

Cristian Alvarez; 🇨🇱 Osorno, Chile