A Comparison of Cognitive and Dynamic Therapy for MDD in Community Settings
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 237
- 试验地点
- 1
- 主要终点
- Hamilton Rating Scale for Depression (HAM-D)
研究概览
简要总结
The goal of this study is to compare supportive-expressive therapy, a type of psychodynamic psychotherapy, with cognitive therapy for the treatment of depression in community mental health consumers.
Hypothesized mediators of treatment will also be examined.
详细描述
The goal of this study is to conduct a randomized, comparative, non-inferiority clinical trial that tests the hypothesis that a widely used form of manualized dynamic psychotherapy (supportive-expressive psychodynamic therapy) is not inferior to cognitive therapy when implemented in community mental health settings for the treatment of major depressive disorder (MDD). The specific aims are (1) to conduct a randomized non-inferiority trial to compare supportive-expressive psychodynamic therapy and cognitive therapy for patients with MDD and (2) to assess the comparative effectiveness of supportive-expressive psychodynamic therapy and cognitive therapy on secondary measures of symptoms, patient functioning, and quality of life.
Patient mediators of outcome will also be examined through an additional grant awarded to Paul Crits-Christoph, Ph.D. This grant was funded by the National Institutes of Mental Health - RO1MH092363-01. This grant is entitled:"The mechanisms of cognitive and dynamic therapy in community settings."
Recruitment will occur solely through community mental health clinics in and around Philadelphia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Confirmed diagnosis of major depressive disorder
- •Able to read at the 4th grade level or higher
- •Willingness to be randomized and participate in research
排除标准
- •Current or past diagnosis of schizophrenia, seizure disorder, bipolar disorder, psychotic features, or clinically significant organic pathology
- •Significant suicidal risk/ideation requiring immediate referral for more intensive treatment, or specific gesture in the last 6 months
- •Current substance abuse or dependence requiring immediate referral to substance abuse program
- •Acute medical problem requiring immediate inpatient treatment
- •Need for referral to a partial hospitalization program
研究组 & 干预措施
Dynamic Therapy
干预措施: Supportive-Expressive Psychodynamic Therapy (Behavioral)
Cognitive Therapy
干预措施: Cognitive Therapy (Behavioral)
结局指标
主要结局
Hamilton Rating Scale for Depression (HAM-D)
时间窗: 6 months
次要结局
- Ways of Responding (WOR)(2 months)
- BASIS-24(6 months)
- Self-Understanding of Interpersonal Patterns Scale-Revised (SUIP-R)(2 months)
- Beck Depression Inventory - II (BDI-II)(6 months)
- Quality of Life Inventory (QOLI)(6 months)
- Dysfunctional Attitudes Scale (DAS)(2 months)
- Medical Outcomes Study 36-Item Short Form (SF-36)(6 months)
- Psychological Distance Scaling Task (PDST)(2 months)