A Comparison of Cognitive and Dynamic Therapy for Depression in Community Settings

Not Applicable

Completed

• Conditions: Major Depressive Disorder
• Interventions: Behavioral: Supportive-Expressive Psychodynamic Therapy; Behavioral: Cognitive Therapy

• Registration Number: NCT01207271
• Lead Sponsor: University of Pennsylvania

Brief Summary

The goal of this study is to compare supportive-expressive therapy, a type of psychodynamic psychotherapy, with cognitive therapy for the treatment of depression in community mental health consumers.

Hypothesized mediators of treatment will also be examined.

Detailed Description

The goal of this study is to conduct a randomized, comparative, non-inferiority clinical trial that tests the hypothesis that a widely used form of manualized dynamic psychotherapy (supportive-expressive psychodynamic therapy) is not inferior to cognitive therapy when implemented in community mental health settings for the treatment of major depressive disorder (MDD). The specific aims are (1) to conduct a randomized non-inferiority trial to compare supportive-expressive psychodynamic therapy and cognitive therapy for patients with MDD and (2) to assess the comparative effectiveness of supportive-expressive psychodynamic therapy and cognitive therapy on secondary measures of symptoms, patient functioning, and quality of life.

Patient mediators of outcome will also be examined through an additional grant awarded to Paul Crits-Christoph, Ph.D. This grant was funded by the National Institutes of Mental Health - RO1MH092363-01. This grant is entitled:"The mechanisms of cognitive and dynamic therapy in community settings."

Recruitment will occur solely through community mental health clinics in and around Philadelphia.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2010-09-21
• Study First Submitted QC: 2010-09-21
• Study First Posted: 2010-09-22
• Study Start: 2010-11
• Primary Completion: 2014-12-09
• Study Completion: 2014-12-09
• Status Verified: 2017-04
• Last Update Submitted: 2017-04-28
• Last Update Posted: 2017-05-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 237

Inclusion Criteria

• Confirmed diagnosis of major depressive disorder
• Able to read at the 4th grade level or higher
• Willingness to be randomized and participate in research

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Exclusion Criteria

• Current or past diagnosis of schizophrenia, seizure disorder, bipolar disorder, psychotic features, or clinically significant organic pathology
• Significant suicidal risk/ideation requiring immediate referral for more intensive treatment, or specific gesture in the last 6 months
• Current substance abuse or dependence requiring immediate referral to substance abuse program
• Acute medical problem requiring immediate inpatient treatment
• Need for referral to a partial hospitalization program

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Dynamic Therapy	Supportive-Expressive Psychodynamic Therapy	-
Cognitive Therapy	Cognitive Therapy	-

Primary Outcome Measures

Name	Time	Method
Hamilton Rating Scale for Depression (HAM-D)	6 months

Secondary Outcome Measures

Name	Time	Method
Beck Depression Inventory - II (BDI-II)	6 months
Quality of Life Inventory (QOLI)	6 months
Dysfunctional Attitudes Scale (DAS)	2 months
Ways of Responding (WOR)	2 months
BASIS-24	6 months
Medical Outcomes Study 36-Item Short Form (SF-36)	6 months	Measure of general functionality
Psychological Distance Scaling Task (PDST)	2 months
Self-Understanding of Interpersonal Patterns Scale-Revised (SUIP-R)	2 months

Trial Locations

Locations (1)

University of Pennsylvania; 🇺🇸 Philadelphia, Pennsylvania, United States