The effect of plasma proteins on periodontal tissue regeneratio

Not Applicable

• Conditions: Vertical interproximal periodontal defects in differing quadrants of the mouth; Oral Health; At least 2 vertical interproximal periodontal defects in differing quadrants of the mouth.

• Registration Number: ISRCTN67624527
• Lead Sponsor: niversity of Bristol

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-10-29
• Last Update Posted: 8 January 2024
• Study Completion: 2028-05-01

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1. Willing to participate and voluntary written informed consent
2. Aged 18 years or older
3. Willing, able and likely to comply with all study procedures and restrictions
4. Good general health with (in the opinion of the investigator) no clinically significant and relevant abnormalities of medical history or oral examination
5. At least 2 vertical interproximal periodontal defects in different quadrants of the mouth as evidenced by radiographic investigation
6. Full mouth Turesky plaque index score <2
7. Non-smoker or have stopped smoking for ?6 months prior to surgery

Exclusion Criteria

1. Pregnant or who are intending to become pregnant over the duration of the study
2. Breastfeeding
3. Current or recurrent disease/dental pathology that could affect the assessments
4. Bleeding disorders
5. Immuno-compromised
6. Current or relevant previous history of serious, severe or unstable physical or psychiatric illness, or any medical disorder that may require treatment or make the participant unlikely to fully complete the study, or any condition that presents undue risk from the study products or procedures.
7. Tooth with less than grade I mobility
8. Known or suspected intolerance or hypersensitivity to the study materials (or closely related compounds) or any of their stated ingredients
9. Use of antibiotics one month prior to start of the study
10. Participation in another clinical study or receipt of an investigational drug within 10 days of the screening visit
11. Recent history of alcohol or other substance abuse
12. Member of the study site or a family relative. The study site for this protocol is the Clinical Trials Unit in the Bristol Dental Hospital. Employees of the Bristol Dental Hospital not associated with the Clinical Trials Unit are eligible to participate
13. Any participant who, in the judgement of the investigator, should not participate in the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified