Immunochistochemical evaluation of Vimentin in triple negative breast carcinoma in young females with its relation to other clinicopathological parameters
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- To determine the frequency of vimentin positivity and its expression levels in TNBC cases in females under 50 years using immunohistochemistry.
研究概览
简要总结
This study aims to evaluate the immunohistochemical expression of vimentin in triple-negative breast carcinoma in females below 50 years of age and to assess its association with clinicopathological parameters. TNBC is an aggressive subtype of breast cancer commonly affecting younger women and lacks targeted therapeutic options. Vimentin, a mesenchymal marker involved in epithelial–mesenchymal transition, has been associated with tumor aggressiveness and poor prognosis in breast carcinoma.
This is a retrospective and prospective observational diagnostic study conducted in the Department of Pathology at a tertiary care center. Formalin-fixed paraffin-embedded resected specimens of TNBC will be evaluated using immunohistochemistry for vimentin expression. The frequency and pattern of vimentin expression will be assessed and correlated with tumor size, histological grade, lymphovascular invasion, lymph node status, and tumor stage.
The study aims to determine whether vimentin expression can serve as a useful prognostic biomarker in young patients with TNBC and contribute to better risk stratification in this high-risk group.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 10.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- Female
入选标准
- •Resected specimens of Invasive ductal carcinoma confirmed on histopathology.
- •Molecular subtype of TNBC confirmed on IHC.
排除标准
- 未提供
结局指标
主要结局
To determine the frequency of vimentin positivity and its expression levels in TNBC cases in females under 50 years using immunohistochemistry.
时间窗: At baseline four weeks to 8 weeks
次要结局
- Correlation of vimentin expression with clinicopathological parameters including tumor size, grade, lymphovascular invasion, lymph node status, and stage.(At baseline.)
研究者
MUSKAAN BHATNAGAR
JNMC WARDHA