Developing and Optimizing Transcranial Magnetic Stimulation for Motor Rehabilitation
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- 入组人数
- 45
- 主要终点
- Effect of TMS on motor evoked potentials
研究概览
简要总结
This study aims to evaluate three different transcranial magnetic stimulation protocols and their impact on motor system neurophysiology and skill learning.
详细描述
Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation method that induces long-term changes in connections between neuronal networks. This and the ability to activate the whole motor system allows the use of TMS to facilitate motor recovery. The motor system has different excitatory states associated with ongoing mu oscillation. Here, the investigators will monitor brain mu oscillations in real-time non-invasively using electroencephalography and modulate the function of the motor system. The investigators will test the impact of three different TMS protocols on motor system neurophysiology and skill learning. These data will provide novel understanding needed to improve TMS approaches for individuals requiring motor rehabilitation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-40 years old
- •Able to read, understand, and sign the informed consent in English
- •Right-handed
排除标准
- •A sensory or physical impairment
- •History of epilepsy or seizures in the family
- •Non-removable metal or electronics (e.g., a cochlear implant, cardiac pacemaker, or implanted electronic devices) in your head or body
- •A head injury with loss of consciousness
- •Diagnosis of psychiatric or neurological disorder
- •Skin defects or active infections on the scalp or hands
- •Pregnancy or breastfeeding
研究组 & 干预措施
Single-pulse TMS over the primary motor cortex
We will administer single-pulse TMS to the primary motor cortex while measuring motor responses and just before a skill-learning task.
干预措施: Transcranial Magnetic Stimulation (TMS) (Device)
Paired-pulse TMS over the primary motor cortex
We will administer paired-pulse TMS to the primary motor cortex while measuring motor responses and just before a skill-learning task.
干预措施: Transcranial Magnetic Stimulation (TMS) (Device)
Sham TMS over the primary motor cortex
We will administer sham TMS to the primary motor cortex while measuring motor responses and before a skill-learning task.
干预措施: Transcranial Magnetic Stimulation (TMS) (Device)
结局指标
主要结局
Effect of TMS on motor evoked potentials
时间窗: Up to 1 second after TMS
Amplitude of the motor evoked potentials in millivolts.
Skill learning speed
时间窗: Up to 12 minutes
Skill learning speed in seconds.
Skill learning accuracy
时间窗: Up to 12 minutes
Skill learning accuracy as the total number of correct responses.
次要结局
未报告次要终点
研究者
Elisa Kallioniemi
Assistant Professor
New Jersey Institute of Technology