The Effect of Renin-Angiotensin System Inhibition on Aortic Dilatation Rate in Patients with Coarctation of the Aorta. - ASPECT study.

niversitair Medisch Centrum Utrecht0 个研究点目标入组 80 人开始时间: 待定最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•- Subject has been diagnosed with CoA.
•- Subject has previously undergone a surgical or transcatheter (balloon dilatation or stenting) intervention for CoA.
•- A previous CMR has been performed on the subject.
•- Subject is at least 16 years of age.
•- Subject is competent to understand the performed procedures, the potential hazards associated with these procedures, and to provide written informed consent.

•- Subject with thoracic aortic dissection prior to study period.
•- Subject who underwent an intervention for an aneurysm of the ascending aorta prior to study period.
•- Subject is currently pregnant or has been pregnant during the study period.
•- Subject has a medical condition which, in the opinion of the investigator, could adversely affect the subject*s safety and/or the interpretation of the results.
•- Subject with a contraindication for CMR with administration of gadolinium-based contrast agent:
•Cardiac pacemaker or implanted cardioverter defibrillator not compatible with CMR.
•Electronic device or implant, such as cochlear implant or insulin pump.
•Past adverse reaction to gadolinium-based contrast agents.
•Severe renal insufficiency (creatinine clearance <30 mL/min/1,73 m²).
•Known claustrophobia.

发起方

niversitair Medisch Centrum Utrecht