Lymphatic Mapping After Previous Breast Surgery

Completed

• Conditions: Breast Cancer; Sentinel Node

• Registration Number: NCT01164748
• Lead Sponsor: Catharina Ziekenhuis Eindhoven

Brief Summary

Rationale: Like in primary breast cancer, prognosis in recurrent breast cancer is correlated with regional lymph node status. Therefore, axillary staging may be warranted in patients with recurrent disease and intact axillary nodes, although this has not been described in guidelines yet. The lymphatic drainage pathways in the breast and/or axilla could have been changed due to prior surgery and/or radiotherapy. These aberrant drainage pathways could be detected with lymphatic mapping and sentinel node biopsy (SNB), leading to a more accurate staging.

Objective: To assess the technical feasibility of lymphoscintigraphy after prior breast surgery. A second goal is to investigate whether or not previous breast surgery (with or without radiotherapy) significantly changes the lymphatic drainage pathways of the breast.

Detailed Description

Not available

Study Timeline

• Status Verified: 2010-07
• Study First Submitted: 2010-07-16
• Study First Submitted QC: 2010-07-16
• Last Update Submitted: 2010-07-16
• Study First Posted: 2010-07-19
• Last Update Posted: 2010-07-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: Not specified

Inclusion Criteria

• treatment with BCT with SNB and/or ALND for primary breast cancer
• previous primary breast cancer located in the upper-outer quadrant of one breast
• Primary breast cancer treatment at least 3 years before the analysis, with or without adjuvant chemo- or hormonal therapy.

Exclusion Criteria

• breast surgery for other reasons than breast cancer
• recurrent breast cancer
• former allergic reaction to 99mTc-colloidal albumin.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Catharina Hospital; 🇳🇱 Eindhoven, Netherlands