Researching trained immunity in SLE patients
- Conditions
- Systemic lupus erythematosuslupus10003816
- Registration Number
- NL-OMON53281
- Lead Sponsor
- Radboud Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
Age between 18 and 70 years old.
Positive SLE diagnosis.
Exclusion Criteria
Lack of informed consent
Current infection
CKD stage 5 or dialysis
Pregnancy
Active cancer
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>1. What are the differences in the transcriptome of circulating monocytes from<br /><br>SLE patients when the disease is in remission or when the disease is active<br /><br>(flares), and how does this differ with the transcriptome of circulating<br /><br>monocytes from healthy individuals?<br /><br><br /><br>2. What are the differences in the epigenome of circulating monocytes from SLE<br /><br>patients when the disease is in remission or when the disease is active<br /><br>(flares), and how does this differ with the epigenome of circulating monocytes<br /><br>from healthy individuals?<br /><br><br /><br>3. What are the differences in the cytokine response of circulating monocytes<br /><br>from SLE patients when the disease is in remission or when the disease is<br /><br>active (flares), and how does this differ with the response of circulating<br /><br>monocytes from healthy individuals?</p><br>
- Secondary Outcome Measures
Name Time Method <p>1. Are there correlations between the trained immunity profile of circulating<br /><br>monocytes (identified by transcriptome, epigenetics, and cytokine response) and<br /><br>the degree of current disease activity in clinical variables of SLE patients?<br /><br><br /><br>2. Are there correlations between the trained immunity profile of circulating<br /><br>monocytes (identified on the basis of the transcriptome, epigenetics, and<br /><br>cytokine response) and the risk of the occurrence of flares in the future.<br /><br><br /><br>3. Are there correlations between the trained immunity profile of circulating<br /><br>monocytes (identified based on the transcriptome, epigenetics, and cytokine<br /><br>response) and inflammatory markers in the blood. </p><br>