Induction of secondary follicle growth by physical stimulation to ovary
Phase 3
Recruiting
- Conditions
- Infertility patients with poor response to gonadotropins
- Registration Number
- JPRN-UMIN000028031
- Lead Sponsor
- Saint Mother Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- 200
Inclusion Criteria
Not provided
Exclusion Criteria
1)Patients with severe ovarian dysfunction who can not retrieve oocytes after ovarian stimulation. 2)Patients with high risk for laparoscopy. 3)anovulatory amenorrhea patient 4)Male infertility patients with Y chromosome microdeletion and chromosome abnormalities. 5)Patients who can not obtain written informed consent. 6)Patients judged to be inappropriate for the study by the physicians.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Comparison of the number of oocytes retrieved after ovarian stimulation with those of base line numbers.
- Secondary Outcome Measures
Name Time Method Comparison of proportions of fertilization, pregnancy and abortion with those of base line levels. Comparison of the levels of molecular markers reflecting the results of Hippo signal suppression in ovarian tissues and serum before and after culture and grafting operation, respectively. Also, we count the number of secondary follicles in grafting tissues by histological analysis. To evaluate the effect of in situ incision of ovarian cortex for secondary follicle growth, we measure the levels of serum AMH and inhibin B derived from granulosa cells of secondary follicles. Based on these data, we attempt to identify a suitable time point for initiation of ovarian stimulation.