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临床试验/NCT03908606
NCT03908606已完成不适用

Prognostic Value of Serum Hs-CRP in Periodontitis Patients With or Without Type 2 Diabetes Following Non-surgical Periodontal Therapy

Cairo University2 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2018年4月11日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
60
试验地点
2
主要终点
clinical attachment level

研究概览

简要总结

the aim of this study was to assess serum levels of high sensitivity c reactive protein in periodontitis patients with and without type 2 diabetes in a trial to analyze its prognostic effect following non-surgical periodontal therapy.

详细描述

Periodontitis and diabetes are chronic disorders with a two-way correlation as they can both stimulate an inflammatory response with subsequent formation of inflammatory mediators and cytokines. C reactive protein is an inflammatory plasma marker having a role in the systemic reaction to inflammation. thus, our aim in the current study was to evaluate serum levels of high sensitivity c reactive protein in periodontitis patients with and without type 2 diabetes in a trial to analyze its prognostic effect following non-surgical periodontal therapy. A total of 60 patients were enrolled in this study. ELISA was used for determination of hs- CRP. Non- surgical periodontal therapy was carried out for all periodontitis patients.

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Parallel
主要目的
Diagnostic
盲法
Single (Outcomes Assessor)

入排标准

性别
All
接受健康志愿者

入选标准

  • Diabetic patients type 2
  • Periodontitis patients

排除标准

  • Pregnant females

研究组 & 干预措施

Periodontitis patients with diabetes type 2

Experimental

scaling and root planing was administered to all patients. Serum samples were collected before and after treatment to assess hs-CRP levels. Glycated hemoglobin was measured before and after treatment

干预措施: Scaling and root planing (Procedure)

Periodontitis patients

Experimental

scaling and root planing will be done to periodontitis patients. Serum samples were collected before and after treatment to assess hs-CRP levels.

干预措施: Scaling and root planing (Procedure)

Healthy control group

No Intervention

We measured serum levels of hs-CRP in all healthy control subjects

结局指标

主要结局

clinical attachment level

时间窗: 3 months

gain in clinical attachment level

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Gihane Gharib Madkour

Associate professor

Cairo University

研究点 (2)

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