A Multicenter Pilot Study to Determine the Pharmacokinetics of Astagraf XL, Prograf and Mycophenolate Mofetil in Renal Transplant Candidates Who Have Undergone Laparoscopic Sleeve Gastrectomy

University of Cincinnati1 site in 1 country26 target enrollmentMay 2014

ConditionsEnd Stage Renal Disease

InterventionsAstagraf XL Prograf Mycophenolate mofetil

DrugsAstagraf XL Prograf Mycophenolate mofetil

Overview

Phase: Phase 4
Intervention: Astagraf XL
Conditions: End Stage Renal Disease
Sponsor: University of Cincinnati
Enrollment: 26
Locations: 1
Primary Endpoint: Area Under Curve (AUC)
Status: Completed
Last Updated: 10 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to evaluate how quickly and to what extent different immunosuppressants are absorbed into the blood (this is called pharmacokinetics) in renal transplant candidates who have undergone a laparoscopic sleeve gastrectomy. The immune system is the body's defense against diseases. It also attacks "foreign" tissues such as a transplanted kidney. Immunosuppressant medications such as Astagraf sustained release (XL), Prograf, and mycophenolate mofetil may be given to suppress the immune system following kidney transplantation and prevent rejection of a transplanted kidney. This study is being performed to determine if patients who undergo laparoscopic sleeve gastrectomy need different doses of immunosuppressant medications.

Detailed Description

Investigators propose a single dose, cross over pharmacokinetic study of Astagraf XL and Prograf® in combination with MMF in RTx candidates that have undergone LSG. Subjects at least three months post LSG and pre-renal transplant will undergo preliminary screening. The study population will consist of 24 male and female subjects, ≥ 18 years old from UC Health University Hospital and The Christ Hospital who meet the inclusion/exclusion criteria. Two PK profiles will be obtained in each subject. Each subject will receive either Astagraf XL 8mg daily or Prograf® 4mg every 12 hours in combination with MMF 1000mg every 12 hours. A full 24 hour PK profile will be constructed. After at least a one week washout period, the patient will be crossed over to the alternative tacrolimus formulation (Astagraf XL or Prograf®) in combination with MMF 1000mg every 12 hours and the PK profile repeated. The immunosuppressants chosen reflect the regimen most commonly prescribed to transplant recipients. Subjects participating in the study will have pharmacokinetic blood samples drawn over a 24 hour time period in order to determine the AUC, Tmax, Cmax, and half-life of tacrolimus, MMF and their metabolites. Samples would be drawn prior to dosing (C0) and at 1, 1.5, 2, 2.5, 3, 4, 6, 8, 12, 12.5, 13, 14, 15, 16, 18, 20 and 24 hours post dosing (18 time points) by venipuncture or IV. This study proposal represents a simple and expeditious method to achieve PK information in patients that have undergone LSG. If desired, study could be expanded to evaluate PK in additional patient groups such as pre and post LSG and/or pre and post renal transplant. The exact sample collection time will be recorded in the case report form. All deviations from the scheduled sampling time of more than 5 minutes for the first 4 hours after the AM dose (predose-4 hr) and first 4 hours of the PM dose (12 hr-16 hr), and more than 10 minutes for all remaining samples (6 hr-8 hr; 18 hr-24 hr) will be reported as a protocol deviation.

Registry

clinicaltrials.gov

Start Date

May 2014

End Date

February 2015

Last Updated

10 years ago

Study Type

Interventional

Study Design

Crossover

Sex

All

Investigators

Sponsor

University of Cincinnati

Responsible Party

Principal Investigator

Tayyab Diwan

Assistant Professor of Surgery

University of Cincinnati

Eligibility Criteria

Inclusion Criteria

•Female or male patient aged \> 18 years old.
•ESRD patient (on dialysis or preemptive) who is a potential candidate for kidney transplantation
•Undergone laparoscopic sleeve gastrectomy procedure \> 3 months prior to enrollment.
•Subjects have signed and dated the informed consent to participate in the study.

Exclusion Criteria

•Patients taking a drug known to interact with Astagraf XL, Prograf®, or MMF.
•Patients that have an allergy to Astagraf XL, Prograf®, or MMF.
•Patients currently taking Astagraf XL, Prograf®, or MMF.
•Post-surgical leak complication
•Patients failing to adhere to post laparoscopic sleeve gastrectomy follow-up recommendations and clinic visits
•Patients with any severe medical condition requiring acute or chronic treatment that in the investigator's opinion would interfere with study participation.
•Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive laboratory test
•Currently taking or planning to initiate of any medications that could interfere with tacrolimus and/or mycophenolate blood levels, including over the counter (OTC) medications, herbal supplements, grapefruit or grapefruit juice.
•Subjects who have been exposed to an investigational therapy within 30 days prior to enrollment or 5 half-lives of the investigational product, whichever is greater.