Dietary Supplementation on Fat Oxidation
- Conditions
- ObesityOverweight
- Registration Number
- NCT06548048
- Lead Sponsor
- Brightseed
- Brief Summary
The purpose of this pilot study is to evaluate the effects of 4 weeks of daily consumption of encapsulated N-trans-caffeoyl tyramine (NCT) and N-trans-feruloyl tyramine (NFT) at a dose of 120 mg/d on measures of fat oxidation in women with overweight or obesity. The hypothesis is that fat oxidation at rest (measured via indirect calorimetry) and over a 24 h period (measured via d31-palmitic acid stable isotope tracer) will be higher in the group receiving the active study product compared to the control product at the end of the 4-week consumption period.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- Female
- Target Recruitment
- 16
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method % deuterium (2H) label from oxidation of d31-palmitic acid Day 1 and Day 28 (each day measurements are done in multiple timepoints of Hour 0, Hour 3, Hour 4, Hour 8, and Hour 24) Percentage recovery of the deuterium (2H) label from oxidation of d31-palmitic acid to water in urine samples collected
- Secondary Outcome Measures
Name Time Method Change in body weight day 1 and day 28 Change in body weight measured in scale
Change in indirect calorimetry measures day 1 and day 28 Substrate utilization associated with RMR derived from the Respiratory Exchange Ratio (RER)
Change in cardiometabolic parameters day 1 and day 28 Fasting Insuline
Related Research Topics
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Trial Locations
- Locations (1)
Biofortis
🇺🇸Addison, Illinois, United States
Biofortis🇺🇸Addison, Illinois, United States