Dietary Supplementation on Fat Oxidation

Not Applicable

Recruiting

• Conditions: Obesity; Overweight
• Interventions: Dietary Supplement: Microcrystaline cellulose; Dietary Supplement: Dietary supplement containing plant derived phenolics

• Registration Number: NCT06548048
• Lead Sponsor: Brightseed

Brief Summary

The purpose of this pilot study is to evaluate the effects of 4 weeks of daily consumption of encapsulated N-trans-caffeoyl tyramine (NCT) and N-trans-feruloyl tyramine (NFT) at a dose of 120 mg/d on measures of fat oxidation in women with overweight or obesity. The hypothesis is that fat oxidation at rest (measured via indirect calorimetry) and over a 24 h period (measured via d31-palmitic acid stable isotope tracer) will be higher in the group receiving the active study product compared to the control product at the end of the 4-week consumption period.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-07-31
• Status Verified: 2024-08
• Study First Submitted: 2024-08-05
• Study First Submitted QC: 2024-08-08
• Last Update Submitted: 2024-08-08
• Study First Posted: 2024-08-12
• Last Update Posted: 2024-08-12
• Primary Completion: 2024-11-05
• Study Completion: 2024-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Female
• Target Recruitment: 16

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo Treatment	Microcrystaline cellulose	-
Active high dose of plant derived phenolics	Dietary supplement containing plant derived phenolics	-

Primary Outcome Measures

Name	Time	Method
% deuterium (2H) label from oxidation of d31-palmitic acid	Day 1 and Day 28 (each day measurements are done in multiple timepoints of Hour 0, Hour 3, Hour 4, Hour 8, and Hour 24)	Percentage recovery of the deuterium (2H) label from oxidation of d31-palmitic acid to water in urine samples collected

Secondary Outcome Measures

Name	Time	Method
Change in body weight	day 1 and day 28	Change in body weight measured in scale
Change in indirect calorimetry measures	day 1 and day 28	Substrate utilization associated with RMR derived from the Respiratory Exchange Ratio (RER)
Change in cardiometabolic parameters	day 1 and day 28	Fasting Insuline

Trial Locations

Locations (1)

Biofortis; 🇺🇸 Addison, Illinois, United States