Secondhand Smoking in Asthmatic Children
Completed
- Conditions
- WheezingAsthma in Children
- Interventions
- Diagnostic Test: Lung functionDiagnostic Test: White blood cell DNA extractionDiagnostic Test: Urinary testing
- Registration Number
- NCT03099902
- Lead Sponsor
- AHEPA University Hospital
- Brief Summary
This study will investigate the interaction between GSTP1 / TNFa polymorphisms and passive smoking in children with asthma/wheezing. Contemporary second hand-smoke exposure will be confirmed by laboratory testing.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 90
Inclusion Criteria
- Subjects 1-18 years old with doctor diagnosed asthma/wheezing
Exclusion Criteria
- Premature birth (< 36 gestation weeks)
- Asthma-like symptoms due to other conditions (infectious, congenital, mechanical)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Cases Lung function Children with asthma/wheezing whose mothers were active smokers during pregnancy Cases White blood cell DNA extraction Children with asthma/wheezing whose mothers were active smokers during pregnancy Controls White blood cell DNA extraction Children without asthma/wheezing whose mothers were active smokers during pregnancy Controls Urinary testing Children without asthma/wheezing whose mothers were active smokers during pregnancy Controls Lung function Children without asthma/wheezing whose mothers were active smokers during pregnancy Cases Urinary testing Children with asthma/wheezing whose mothers were active smokers during pregnancy
- Primary Outcome Measures
Name Time Method GSTP1 and TNFa variants in children with asthma 0 days
- Secondary Outcome Measures
Name Time Method