Incidence, Severity and Treatment of Delirium in Cardiac Surgery Patients: A Before-after Study

Not Applicable

Completed

• Conditions: Delirium
• Interventions: Other: systematic screening and treatment of delirium

• Registration Number: NCT01774240
• Lead Sponsor: Rigshospitalet, Denmark

Brief Summary

Delirium is a common yet under diagnosed condition in hospitalized patients, and the incidence have not previously been described in Danish cardiac surgery patients. The present study seeks to describe the incidence and duration of delirium in this group of patients, before and after the introduction of standardized screening tool and a guideline for treatment of delirium after cardiac surgery.

Detailed Description

Delirium is a common yet under diagnosed condition in cardiac surgery patients, and may cause prolonged cognitive impairment and increased risk of complications. Patients are at risk of e.g. pulling catheters and lines and may fall attempting to get out of bed. The aging patient population present with many risk factors for developing delirium, but diagnostic tools have been few. Almost 50% present with hypoactive delirium, which is often not diagnosed, nor treated correctly. To optimize effect, treatment should be initiated early, maintained until clinical improvement is observed, and then tapered gradually. Recently, Delirium Observation Screening scale (DOS scale) was developed and validated in elective cardiac surgery patients in the Netherlands, with interesting results. This encouraged us to evaluate the effects of systematic delirium screening and treatment in cardiac surgery patients. To our knowledge, no prior studies have evaluated use of DOS scale in this context.

OBJECTIVES To evaluate the incidence and severity of delirium, and the effects of standardized treatment in a population of Danish cardiac surgery patients.

Study Timeline

• Study Start: 2012-04
• Primary Completion: 2012-10
• Study Completion: 2012-12
• Study First Submitted: 2013-01-01
• Study First Submitted QC: 2013-01-20
• Study First Posted: 2013-01-23
• Status Verified: 2023-11
• Last Update Submitted: 2023-11-16
• Last Update Posted: 2023-11-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 230

Inclusion Criteria

• adult patients admitted for cardiac surgery at department of cardiothoracic surgery, Rigshospitalet, denmark

Exclusion Criteria

• patients under age 18,
• patients that died within 24 hours after admission.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
after	systematic screening and treatment of delirium	systematic screening and treatment of delirium

Primary Outcome Measures

Name	Time	Method
number of delirium free days	14 days	number of delirium free days are calculated as percentage of length of stay (LOS) in days.; Participants will be followed for the duration of hospital stay, an expected average of 2 weeks

Secondary Outcome Measures

Name	Time	Method
complication rates	14 days	complications: respiratory, re-operation, infection, acute kidney injury (AKI), cerebral, cardiac, bleeding.; participants will be followed for the duration of hospital stay, an expected average of 2 weeks

Trial Locations

Locations (1)

Department of cardiothoracic surgery and intensive care 4142, Rigshospitalet, Blegdamsvej 6; 🇩🇰 Copenhagen, Denmark