Algorithm development through artificial intelligence for the triage of stroke patients in the ambulance with electroencephalography

Recruiting

Conditions: cerebral infarction
Stroke
10007963

Registration Number: NL-OMON52101

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 1192

Inclusion Criteria

- Suspected acute ischemic stroke, as assessed by the attending ambulance
paramedic, or patients with a known LVO stroke who are transferred for EVT;
- Onset of symptoms or, if onset not witnessed, last seen well <24 hours ago;
- Age of 18 years or older;
- Written informed consent by patient or legal representative.

Exclusion Criteria

- Injury or active infection of electrode cap placement area.
- Suspected COVID-19 infection.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Based on the EEG data, and using the final diagnosis established by an<br /><br>adjudication committee as the gold standard, one or more novel AI-based EEG<br /><br>algorithms will be developed with maximal diagnostic accuracy to identify<br /><br>patients with an LVO stroke of the anterior circulation in a population of<br /><br>patients with suspected AIS. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- AUC, sensitivity, specificity, positive predictive value (PPV) and negative<br /><br>predictive value (NPV) of the AI-STROKE algorithms based on ambulant EEG for<br /><br>diagnosis of LVO of the anterior circulation in suspected AIS patients in the<br /><br>prehospital setting;<br /><br>- AUC, sensitivity, specificity, PPV and NPV of existing EEG algorithms based<br /><br>on ambulant EEG for diagnosis of LVO of the anterior circulation in suspected<br /><br>AIS patients in the prehospital setting;<br /><br>- AUC, sensitivity, specificity, PPV and NPV of existing and newly developed<br /><br>EEG algorithms based on ambulant EEG for detection of LVO stroke of the<br /><br>posterior circulation, intracerebral hemorrhage, transient ischemic attack, and<br /><br>stroke mimics;<br /><br>- Technical and logistical feasibility (e.g. in terms of EEG channel<br /><br>reliability) of paramedics performing ambulant EEG in patients with a suspected<br /><br>AIS in the prehospital setting;</p><br>