Post -transplantation Cyclophosphamide as Graft Versus Host Disease prophylaxis in Children with ß-Thalassemia Major undergoing Hematopoietic Stem Cell Transplantatio

Phase 3

• Conditions: Haematological Disorders; Paediatrics

• Registration Number: PACTR202311877246623
• Lead Sponsor: faculty of medicine tanta university

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-11-19
• Last Update Posted: 4 March 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Children with ß-thalassemia major (Pesaro class I, II) undergoing allogeneic peripheral blood stem cell transplantation from matched related donor aged 2- 18 years.

Exclusion Criteria

i.Children with ß-thalassemia major (Pesaro class III).
ii.Conditions with contraindication to cyclophosphamide use as ( systemic infections , uric acid kidney stones , inflammation of bladder with hemorrhage , obstruction of any part of the urinary tract , bloody urine , kidney disease with likely reduction in kidney function , children with a previous hypersensitivity to it .

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Acute Graft versus host disease

Secondary Outcome Measures

Name	Time	Method
chronic Graft versus host disease