ISRCTN32052878Completed未知
Studying Cough in Asthma phenotypes
niversity Hospital of South Manchester NHS Foundation Trust (UK)0 sites100 target enrollmentStarted: November 29, 2013Last updated:
Conditions
Trial Snapshot
- Phase
- 未知
- Status
- Completed
- Sponsor
- Enrollment
- 100
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Sex
- All
Inclusion Criteria
- •1. Aged 18 years or over
- •2. Person with a primary or secondary care doctor diagnosis of asthma
- •3. The subject is treated with:
- •3.1. Short-acting beta 2 agonist
- •3.2. AND/OR inhaled corticosteroid (=500 mcg fluticasone propionate daily or equivalent)
- •3.3. AND/OR a long-acting beta 2 agonist
- •3.4. AND/OR a leukotriene receptor antagonist
- •4. Controlled or has partial asthma control according to the GINA classification
Exclusion Criteria
- •1. Symptoms of upper respiratory tract infection (URTI) in the last 1 month which have not resolved.
- •2. Lower respiratory tract infection or pneumonia in the last 6 weeks.
- •3. Current smoker or ex-smoker with =10 pack-year smoking history, abstinence of 6 months or lesser
- •4. Asthma exacerbation in the previous month requiring an increase or starting of an ICS or OCS
- •5. Asthma medication which includes theophylline or anti-cholinergic drugs.
- •6. Subject has changed asthma medication within the past 4 weeks prior to screening
- •7. A previous asthma exacerbation requiring Intensive Care Unit (ICU) admission.
- •8. Significant other primary pulmonary disorders, in particular; pulmonary embolism, pulmonary hypertension, interstitial lung disease, lung cancer, cystic fibrosis, emphysema or bronchiectasis.
- •9. Pregnancy or breast-feeding
- •10. Use of ACE inhibitors
- •11. Any centrally acting medication which in the view of the investigator could alter the sensitivity of the cough reflex
- •12. History of psychiatric illness, drug or alcohol abuse which may interfere in the participation of the trial.
Investigators
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