Studying Cough in Asthma phenotypes

Not Applicable

Completed

• Conditions: Mild to moderate asthmatics; Respiratory; Asthma

• Registration Number: ISRCTN32052878
• Lead Sponsor: niversity Hospital of South Manchester NHS Foundation Trust (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2013-11-29
• Last Update Posted: 20 February 2017

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1. Aged 18 years or over
2. Person with a primary or secondary care doctor diagnosis of asthma
3. The subject is treated with:
3.1. Short-acting beta 2 agonist
3.2. AND/OR inhaled corticosteroid (=500 mcg fluticasone propionate daily or equivalent)
3.3. AND/OR a long-acting beta 2 agonist
3.4. AND/OR a leukotriene receptor antagonist
4. Controlled or has partial asthma control according to the GINA classification

Exclusion Criteria

1. Symptoms of upper respiratory tract infection (URTI) in the last 1 month which have not resolved.
2. Lower respiratory tract infection or pneumonia in the last 6 weeks.
3. Current smoker or ex-smoker with =10 pack-year smoking history, abstinence of 6 months or lesser
4. Asthma exacerbation in the previous month requiring an increase or starting of an ICS or OCS
5. Asthma medication which includes theophylline or anti-cholinergic drugs.
6. Subject has changed asthma medication within the past 4 weeks prior to screening
7. A previous asthma exacerbation requiring Intensive Care Unit (ICU) admission.
8. Significant other primary pulmonary disorders, in particular; pulmonary embolism, pulmonary hypertension, interstitial lung disease, lung cancer, cystic fibrosis, emphysema or bronchiectasis.
9. Pregnancy or breast-feeding
10. Use of ACE inhibitors
11. Any centrally acting medication which in the view of the investigator could alter the sensitivity of the cough reflex
12. History of psychiatric illness, drug or alcohol abuse which may interfere in the participation of the trial.

Study & Design

• Study Type: Observational
• Study Design: Not specified