Association between pain, mastication and inflammation during treatment with different orthodontic appliances

Not Applicable

• Conditions: Activating Appliances; Saliva; Cytokines; Mastication; Pain.; E06.658.453.560.100; G07.203.650.283.500; C23.888.592.612; D12.644.276.374

• Registration Number: RBR-96dpjz
• Lead Sponsor: Aline Medeiros

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-03-02
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

age range from 12 to 35 years old; need for orthodontic treatment; with dental crowding between 4 and 8 mm in the upper arch; with proper oral hygiene; no caries; both sexes.

Exclusion Criteria

symptoms of temporomandibular joint dysfunction; chronic use of anti-inflammatory drugs or antibiotics; with periodontal disease with generalized probing depth of 3 mm at the test sites; with craniofacial anomalies; wearing orthodontic devices that cause discomfort.

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Expected outcome 1:To assess pain levels, inflammatory cytokines, and chewing quality during treatment with different types of orthosontic appliances. Pain perception will be assessed by visual analogue scale, chewing quality assessed by the Chewing Quality Assessment Questionnaire (QAQM) and cytokine levels assessed by the Flow Cytometry Test (BD ™ CBA). Orthodontic treatments with aesthetic aligners are expected to have lower pain, better chewing quality and less inflammatory cytokines. Levels of 5% will be adopted for pre and post intervention measurements.

Secondary Outcome Measures

Name	Time	Method
o secondary outcomes are expected