NCT04512131已完成不适用
Impact of Dialysis Modality on Coagulation and Platelet Function in Critically Ill Patients: Intermittent Hemodialysis vs. Continuous Renal Replacement Therapy
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- clotting time (CT) in EXTEM in rotational thromboelastometry (ROTEM)
研究概览
简要总结
The investigators will evaluate the impact of dialysis modality (intermittent hemodialysis or continuous renal replacement therapy) in coagulation and platelet function in critically ill patients
详细描述
An prospective observational study will be conducted to confirm the impact of two dialysis modalitites on coagulation and platelet function in critically ill patients requiring renal replacement therapy using laboratory test, Multiplate and ROTEM.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Critically ill adult patients in surgical intensive care unit who require renal replacement therapy
排除标准
- •Patients treated with anti-coagulation therapy due to thrombosis/embolism
- •Patients who take anti-platelet drug due to cardiac or cerebrovascular diseased
- •Patients treated with pharmacological prophylaxis of deep vein thrombosis
- •Patients who received blood products within 24 hours of dialysis initiation
- •Patients who do not want life-sustaining care including renal replacement therapy
结局指标
主要结局
clotting time (CT) in EXTEM in rotational thromboelastometry (ROTEM)
时间窗: before and after applying each mode of dialysis (4 hours in intermittent hemodialysis and 48 hours in continuous renal replacement therapy
the difference of changes in CT in EXTEM of ROTEM (seconds)
次要结局
- platelet count(before and after applying each mode of dialysis (4 hours in intermittent hemodialysis and 48 hours in continuous renal replacement therapy)
- the amount of blood transfusion(24 hours)
- hemodynamic changes(24 hours)
- D-dimer(before and after applying each mode of dialysis (4 hours in intermittent hemodialysis and 48 hours in continuous renal replacement therapy)
- Protein S(before and after applying each mode of dialysis (4 hours in intermittent hemodialysis and 48 hours in continuous renal replacement therapy)
- Multiplate® platelet function analysis area under curve unit(before and after applying each mode of dialysis (4 hours in intermittent hemodialysis and 48 hours in continuous renal replacement therapy)
- clot formation time (CFT) in EXTEM(before and after applying each mode of dialysis (4 hours in intermittent hemodialysis and 48 hours in continuous renal replacement therapy)
- Amplitude 10 minutes after CT (A10) in EXTEM(before and after applying each mode of dialysis (4 hours in intermittent hemodialysis and 48 hours in continuous renal replacement therapy)
- Maximal clot firmness (MCF) in EXTEM(before and after applying each mode of dialysis (4 hours in intermittent hemodialysis and 48 hours in continuous renal replacement therapy)
- α-angle in EXTEM(before and after applying each mode of dialysis (4 hours in intermittent hemodialysis and 48 hours in continuous renal replacement therapy)
- prothrombin time(before and after applying each mode of dialysis (4 hours in intermittent hemodialysis and 48 hours in continuous renal replacement therapy)
- activated partial thromboplastin time(before and after applying each mode of dialysis (4 hours in intermittent hemodialysis and 48 hours in continuous renal replacement therapy)
- fibrinogen(before and after applying each mode of dialysis (4 hours in intermittent hemodialysis and 48 hours in continuous renal replacement therapy)
- Protein C(before and after applying each mode of dialysis (4 hours in intermittent hemodialysis and 48 hours in continuous renal replacement therapy)
- changes of characteristics or amount of drainage(24 hours)
研究者
Ho Geol Ryu
Associate professor
Seoul National University Hospital
研究点 (1)
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