跳至主要内容
临床试验/CTRI/2024/01/061524
CTRI/2024/01/061524已完成3 期

Evaluation of rehydrating efficacy of Trushna-Nigrahana Mahakashaya in Exercise-induced Dehydration in healthy Individuals

Central Council for Research in Ayurvedic Sciences1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2024年2月1日最近更新:

试验速览

阶段
3 期
状态
已完成
入组人数
30
试验地点
1
主要终点
At the end of the study, we would be able to evaluate the Rehydrating Efficacy of Trushna

研究概览

简要总结

Exhaustive physical work is common in athletes and certain occupations like firefighting which

imposes considerable physiological demands, which is exacerbated by impaired heat dissipation due

to environmental heat stress. Specifically, during moderate intensity exercise in the heat, sweatinduced

water loss can be profound. Dehydration is an imbalance between fluid ingestion and loss,

which may lead to dysfunction, illness, and likely increases susceptibility to heat related illness or

injury.

Fluid replacement before and during exercise is unlikely to be sufficient to counterbalance the

ongoing fluid loss. This is especially true during prolonged exposure to a hot environment and in

long duration games like Cricket, Football, Hockey etc. An athlete is then faced with the possibility

of being significantly dehydrated when having to compete again soon. Also, not having enough

hydration can have its effect on the athlete’s performance and not being able to perform as per one’s

capacity leads to added amount of stress in their life.

Hence, a decision must be made on the most effective post-exercise rehydration strategy to restore

body fluid balance.

If there is limited time (~2 hrs) before the next event, an athlete should replace fluid loss in order to

achieve rehydration. The restoration of body fluid losses is necessary for optimal cardiovascular

function and thermoregulation during subsequent exercise (Costill and sparks, 1973, Morimoto et al.

1983).

One of the factors in achieving optimal post exercise rehydration is that drink volume should be

greater than the volume of fluid loss. (Shirreffs et al., 1996). Drink palatability is important since an

individual will not drink a sufficient quantity of drink he/she does not like (Hubbard et al. 1990).

Rehydration after exercise requires not only replacement of volume loss but also replacement of

electrolytes and primarily sodium lost in the sweat.

Hence, the present study is taken up for evaluating the rehydrating efficacy of Trushna Nigrahana

Mahakashaya in Exercise-Induced Dehydration.

研究设计

研究类型
Interventional
分配方式
Randomized
盲法
Participant Blinded

入排标准

年龄范围
20.00 Year(s) 至 35.00 Year(s)(—)
性别
All

入选标准

  • Individuals aged between 20 to 35 years, who are apparently healthy, without any discrimination of gender, caste and religion.
  • Individuals having their BMI between 18.5 kg/m2 and 24.9 kg/m
  • Individuals who will give written consent for study.

排除标准

  • Individuals having any known systemic disorders, Diabetes Mellitus, Thyroid disorders, Gynaecological diseases, any metabolic disorders, musculoskeletal disorders and any type of Cancers.
  • Individuals with a history of hypertension and participants who’s B.P during the initial screening on the day of study will be equal to or more than 140/90 mmHg and Pulse rate equal to or more than 100/minute.
  • Individuals who have undergone any surgery in the last 2 years.
  • Individuals who are on any kind of medications or are on any kind of a special diet.
  • Individuals who do extensive exercises on a regular basis.
  • Pregnant women and Lactating mothers.
  • Any other condition which can jeopardize the outcome of the research.

结局指标

主要结局

At the end of the study, we would be able to evaluate the Rehydrating Efficacy of Trushna

时间窗: Analysis of data obtained before dehydration, immediately post dehydration, | and 90 minutes post-rehydration will be assessed and compared.

Nigrahana Mahakashaya in Exercise-induced dehydration, in healthy individuals.

时间窗: Analysis of data obtained before dehydration, immediately post dehydration, | and 90 minutes post-rehydration will be assessed and compared.

Objective Criteria:

时间窗: Analysis of data obtained before dehydration, immediately post dehydration, | and 90 minutes post-rehydration will be assessed and compared.

1. Urine Volume

时间窗: Analysis of data obtained before dehydration, immediately post dehydration, | and 90 minutes post-rehydration will be assessed and compared.

2. Urine Colour

时间窗: Analysis of data obtained before dehydration, immediately post dehydration, | and 90 minutes post-rehydration will be assessed and compared.

3. Urine Specific Gravity

时间窗: Analysis of data obtained before dehydration, immediately post dehydration, | and 90 minutes post-rehydration will be assessed and compared.

4. Serum Osmolality

时间窗: Analysis of data obtained before dehydration, immediately post dehydration, | and 90 minutes post-rehydration will be assessed and compared.

次要结局

  • Subjective criteria:(1. Thirst)

研究者

申办方类型
Government funding agency
责任方
Principal Investigator
主要研究者

Dr Riddhi Sudhir Bhatt

Pt. Khushilal Sharma Government Autonomous Ayurveda College and Institute, Bhopal

研究点 (1)

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