Probiotic supplementation in pregnant women with intrauterine growth restrictio

Phase 3

Recruiting

Conditions: Intrauterine growth restriction.
Intrauterine growth restriction
o36.5

Registration Number: IRCT20140525017827N13

Lead Sponsor: Shiraz University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Female

Target Recruitment: 50

Inclusion Criteria

Age 18 to 40 years
Women's BMI should be in the range 19.5-29.9
Gravid 1
Mean UAPI in the study group > 2.53
Gestational age 11 to 13 weeks and six days
uterine vascular resistance is high

Exclusion Criteria

Liver and kidney disease
Thyroid disorders
Complete bed rest

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Total plasma antioxidant capacity (TAC). Timepoint: before starting medications and at 28 weeks. Method of measurement: Benzie and Strain methods by calorimetric method using Cusabio Biotech Co.;Plasma Glutathione (GPX) Activity. Timepoint: Before starting medications and at 28 weeks. Method of measurement: Beutler method using Cusabio Biotech Co.;Malondialdehyde (MDA). Timepoint: Before starting medications and at 28 weeks. Method of measurement: TBARS method.

Secondary Outcome Measures

Name	Time	Method
ipid profiles of total cholesterol, HDL-C and triglyceride concentrations. Timepoint: Before starting medications and at 28 weeks. Method of measurement: Enzymatic method using Selectra II autoanalyzer.;Inflammatory markers A. Inflammatory factor hs-CRP. Timepoint: Before starting medications and at 28 weeks. Method of measurement: ELISA device (immunoassay method).;Nitric Oxide Inflammatory Marker Nitric Oxide Amount. Timepoint: Before starting medications and at 28 weeks. Method of measurement: The grease reaction is measured.;Fasting blood sugar and insulin resistance. Timepoint: Before starting medications and at 28 weeks. Method of measurement: Glucose oxidase / peroxidase assay using commercially available kits.