The effects of a 2-week very low-calorie liquid diet prior to liver surgery for patients with fatty liver

Not Applicable

• Conditions: iver surgery; Surgery

• Registration Number: ISRCTN19701345
• Lead Sponsor: niversity Hospitals Plymouth NHS Trust

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-03-20
• Last Update Posted: 8 July 2024
• Study Completion: 2025-03-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 72

Inclusion Criteria

1. Adult patients =18 years
2. Able to provide informed consent
3. Patients with hepatic steatosis (fatty liver) with or without non-alcohol steatohepatitis (NASH) requiring liver resection
4. Patients selected for liver resection surgery for treatment of metastases, hepatocellular carcinoma, gallbladder cancer, peripheral cholangiocarcinoma, or pre-malignant hepatic tumours

Exclusion Criteria

1. Patients with normal background liver on pre-op MRI
2. Patients with cirrhosis with or without signs of portal hypertension
3. Pregnant women
4. Patients that cannot tolerate low fat diet or are allergic or intolerant to components of VLCD sachets
5. Patients who are unable to complete a food diary
6. Patients who are underweight (BMI <20 kg/m²)
7. Patients who are lactose intolerant
8. Patients who follow a vegan diet
9. Patients who report unintentional weight loss of >5% in 0-3 months or >10% in up to 6 months

Study & Design

• Study Type: Interventional
• Study Design: Not specified