Posterior Macular Adhesion: A Potential Risk Factor for Non-exudative Age Related Macular Degeneration (AMD) to Develop Exudative AMD

• Conditions: Dry Age-related Macular Degeneration; Detachment of the Posterior Hyaloid
• Interventions: Device: ultrasound; Device: OCT

• Registration Number: NCT00926861
• Lead Sponsor: The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery

Brief Summary

Choroidal neovascularisation in age related macular degeneration is one of the major causes of legal blindness in the western world existing in two major occurences, the dry and the wet form.The etiology of age related macular degeneration is yet unknown. Genetic factors, oxidative stress, Ischaemia, and aging of the retinal pigment epithelium are discussed as etiologic factors. The risk of rapid vision loss is much higher in wet AMD, a dry form may transform to a wet form. From a prior study the investigators know that the posterior hyaloid is significantly more frequent attached in wet AMD. This study is conducted to examine whether the attached posterior hyaloid is a risk factor to develop wet AMD in dry AMD cases.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2009-06-23
• Study First Submitted QC: 2009-06-23
• Study First Posted: 2009-06-24
• Study Start: 2009-07
• Status Verified: 2010-06
• Last Update Submitted: 2010-06-08
• Last Update Posted: 2010-06-09
• Primary Completion: 2012-12
• Study Completion: 2012-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 320

Inclusion Criteria

• Dry MD
• Age over 50 years

Exclusion Criteria

• Macular pathologies other than age related macular degeneration (like diabetic maculopathy, macular pucker, macular hole)
• Prior vitrectomy or buckle surgery
• Uveitis posterior, multifocal chorioiditis
• Pathologic myopia
• Diabetic retinopathy
• Visualization of the macula not possible (dens cataract, vitreous haemorrhage)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Dry AMD	ultrasound	male or female persons aged over 50 years with dry age-related macular degeneration
Dry AMD	OCT	male or female persons aged over 50 years with dry age-related macular degeneration

Primary Outcome Measures

Name	Time	Method
Number of eyes with non-exudative AMD with attached and detached posterior vitreous cortex developing exudative AMD	24 months

Secondary Outcome Measures

Name	Time	Method
Distance acuity	24 months
Age	24 months
Smoking	24 months
Obesity	24 months
Lesion classification (AREDS)	24 months

Trial Locations

Locations (1)

Ludwig Boltzmann Institute for Retinology and Biomicroscopic Lasersurgery; 🇦🇹 Vienna, Austria