Evaluation of hormones involved in appetite regulation after return to pre-pregnancy weight in women with and without post-partum weight retentio

Not Applicable

Withdrawn

• Conditions: Diet and Nutrition - Obesity; post-pregnancy weight gain

• Registration Number: ACTRN12618001653257
• Lead Sponsor: Priya Sumithran

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-10-05
• Last Update Posted: 15 July 2019

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Female
• Target Recruitment: 74

Inclusion Criteria

Women with no previous history of obesity, who were normal weight (BMI 18.5-24.9 kg/m2) prior to a recent term (37+ weeks) singleton pregnancy, and are now 12 (± 2) months post-partum. Two groups of women will be recruited: those who have returned to within 2kg of their pre-pregnancy weight (group A), and those who remain 10% or more above pre-pregnancy weight (group B).

Exclusion Criteria

Currently pregnant, smoking or taking medications which may affect weight

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Plasma leptin, per kg of fat mass[Four weeks after return to pre-pregnancy weight (estimated to take up to 3 months in group B, and at study entry in group A). Leptin/fat mass for women who do not return to their pre-pregnancy weight will not be included in the primary outcome.]

Secondary Outcome Measures

Name	Time	Method
Changes in circulating (blood) levels of hormones involved in the compensatory response to weight loss (exploratory)[From baseline (pre-weight loss) to after return to pre-pregnancy weight (group B)];DNA methylation profiles at weight-relevant loci (exploratory) in peripheral blood cells[12 months post-partum]