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临床试验/NCT00316316
NCT00316316已完成1 期

Cognitive Behavioral Therapy Plus Motivational Interviewing for Obsessive Compulsive Disorder

New York State Psychiatric Institute1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2006年3月最近更新:
适应症

试验速览

阶段
1 期
状态
已完成
入组人数
30
试验地点
1
主要终点
Obsessive-compulsive symptoms

研究概览

简要总结

This study will determine the effectiveness of adding motivational interviewing to cognitive behavioral therapy, consisting of exposure and ritual prevention, in improving treatment outcomes in people with obsessive-compulsive disorder.

详细描述

Obsessive Compulsive Disorder (OCD) is a chronic and debilitating anxiety disorder. People with OCD often experience recurrent unwanted thoughts, or obsessions. Some examples of obsessions include the following: repetitive fears of causing harm or being harmed; fears of contamination and illness; fears of making mistakes; intrusive distressing sexual or religious imagery; and fears of losing things. In an effort to relieve anxiety about these obsessions, people with OCD develop repetitive behaviors called compulsions. Some examples of compulsions include the following: repetitive washing and cleaning; excessive checking; excessive ordering and arranging; and extreme hoarding and saving. These thoughts and behaviors interfere with everyday life to a great extent. Cognitive behavior therapy (CBT) with exposure and ritual prevention (EX/RP) is a standard treatment for OCD. EX/RP involves both imaginary and real exposure to situations or settings that may stimulate OCD behavior, and it requires that patients refrain from ritualizing. Motivational interviewing (MI) may help to enhance an individual's motivation to change by exploring and resolving ambivalence. This study will determine the effectiveness of adding MI to CBT that consists of EX/RP in improving treatment outcome in people with OCD.

Participants in this single-blind study will be randomly assigned to receive either standard CBT with EX/RP or CBT with EX/RP plus MI. All participants will report to the study site twice weekly for both therapy and assessments for a total of 2 months. Assessments will include interviews and self-rating forms. No medication will be administered during this study. However, participants will continue on any medication that they are taking at the time of study entry. All participants will be assessed for outcomes upon study completion. Participants who respond to therapy will be assessed again 6 months following study completion.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Single (Outcomes Assessor)

入排标准

年龄范围
18 Years 至 70 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Primary diagnosis of OCD as defined by DSM-IV
  • Obsessions and/or compulsions must have been present for at least one year
  • At pre-treatment, a minimum on Y-BOCS on items 1-10 of 16
  • If on psychiatric medication, patient has been on stable SRI dose for a minimum of 12 weeks (and four weeks for concomitant OCD meds,e.g., benzos and antipsychotics) and plans to remain on a stable dose for the duration of the EX/RP+MI treatment.
  • Able to provide informed consent
  • No prior adequate EX/RP treatment (defined as at least 8 exposure sessions that include response prevention instructions and between sessions assignments in a 2 month period)
  • Based on hx, subject is unlikely to require a change in med during the course of EX/RP/EX/RP+MI treatment

排除标准

  • Any additional medical or psychiatric conditions that could make participation in the study medically inadvisable
  • Currently receiving psychotherapy at another clinic

结局指标

主要结局

Obsessive-compulsive symptoms

时间窗: Measured at Months 2 and 8

次要结局

  • Adherence, depression, insight, and quality of life(Measured at Months 2 and 8)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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