Effects of Exercise Training on Cognitive Function and Neurotrophic Factors in Overweight Adults

Not Applicable

Completed

• Conditions: Cognitive Function; Motor Activity; Obesity
• Interventions: Other: Non-exercise; Behavioral: Resistance training

• Registration Number: NCT02915913
• Lead Sponsor: Universidad Santo Tomas

Brief Summary

The BrainFit Study aims to examine acute effects of High Intensity Interval- vs Resistance or Combined program has benefits on Cognitive Function as well as on secretion and regulation of neurotrophic factors or neurotrophins in a cohort of sedentary, overweight adults (aged 18-30 years) from Bogota, Colombia.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-09
• Study First Submitted: 2016-09-22
• Study First Submitted QC: 2016-09-23
• Study First Posted: 2016-09-27
• Primary Completion: 2016-12
• Study Completion: 2016-12
• Status Verified: 2018-10
• Last Update Submitted: 2018-10-10
• Last Update Posted: 2018-10-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 60

Inclusion Criteria

• Written informed consent.
• Interested in improving health and fitness.
• Central obesity: waist circumference ≥90cm
• Body mass index ≥ 26 kg/m(2)

Exclusion Criteria

• Systemic infections.
• Weight loss or gain of >10% of body weight in the past 6 months for any reason.
• Currently taking medication that suppresses or stimulates appetite.
• Uncontrolled hypertension: systolic blood pressure 160 mm Hg or diastolic blood pressure 95 mm Hg on treatment.
• Gastrointestinal disease, including self-reported chronic hepatitis or cirrhosis, any episode of alcoholic hepatitis or alcoholic pancreatitis within past year, inflammatory bowel disease requiring treatment in the past year, recent or significant abdominal surgery (e.g., gastrectomy).
• Asthma.
• Diagnosed diabetes (type 1 or 2), fasting impaired glucose tolerance (blood glucose 118 mg/dL), or use of any anti-diabetic medications.
• Currently taking antidepressant, steroid, or thyroid medication, unless dosage is stable (no change for 6 months).
• Any active use of illegal or illicit drugs.
• Current exerciser (>30 min organized exercise per week).
• Indication of unsuitability of current health for exercise protocol (PARQ).

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
Non-exercise	Non-exercise	Non-exercise
Resistance training	Resistance training	One session for 30-60 minutes of resistance exercise

Primary Outcome Measures

Name	Time	Method
Change from Baseline in Brain-derived neurotrophic factor	Baseline and 60 minutes immediately after the interventions ends	Measurement of serum Brain-derived neurotropic factor true blood samples.

Secondary Outcome Measures

Name	Time	Method
Change from Baseline in Neurotrophin-3	Baseline and 60 minutes immediately after the interventions ends
Change from Baseline in Neurotrophin-4	Baseline and 60 minutes immediately after the interventions ends
Change from Baseline change in Cognitive Function	Baseline and 60 minutes immediately after the interventions ends	Cognitive Performance Test (BPT) computerized cognitive assessment battery developed by Lumos Labs, Inc.

Trial Locations

Locations (1)

Robinson Ramírez-Vélez; 🇨🇴 Bogota, Cundinamarca, Colombia