Association Between Metabolic Syndrome and Serum Nerve Growth Factor Levels in Women With Overactive Bladder
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- nerve growth factor levels
研究概览
简要总结
Nerve growth factor (NGF-R) receptors are between the detrusor muscle fibers and can cause afferent signals. Metabolic syndrome and obesity have been advocated to be risk factors for the development of overactive bladder.
详细描述
Overactive bladder is a clinical syndrome characterized urgency, frequency and nocturia. Infection or other obvious causes must be excluded. The overactive bladder is loss of inhibition of the detrusor muscle during the filling or emptying of the bladder.
Specific receptors and neurotransmitters have role in development of overactive bladder. These includes adrenergic, cholinergic, non-adrenergic, non-cholinergic receptors and interstitial cells.
Nerve growth factor (NGF-R) receptors are between the detrusor muscle fibers and can cause afferent signals. Metabolic syndrome and obesity have been advocated to be risk factors for the development of overactive bladder. The investigators believe that our findings will shed light on treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •women with urgency, nocturia and frequency
- •Abdominal obesity, defined as a waist circumference in men ≥88 cm
- •Serum triglycerides ≥150 mg/dL (1.7 mmol/L) or drug treatment for elevated triglycerides
- •Serum HDL cholesterol <40 mg/dL (1 mmol/L) in men and <50 mg/dL (1.3 mmol/L) in women or drug treatment for low HDL-C
- •Blood pressure ≥130/85 mmHg or drug treatment for elevated blood pressure
- •Fasting plasma glucose (FPG) ≥100 mg/dL (5.6 mmol/L) or drug treatment for elevated blood glucose
排除标准
- •Chronic obstructive pulmonary disease allergy
- •Psychiatric disorders
- •Urinary tract infection
- •Neurological diseases
- •Metabolic diseases
- •Pure stress or mixed urinary incontinence
- •History of pelvic surgery
- •Diabetes mellitus
结局指标
主要结局
nerve growth factor levels
时间窗: 3 months
association between nerve growth factor levels and overactive bladder
次要结局
- urge incontinence(3 months)
- overactive bladder symptoms(3 months)